| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nitrogen regulatory protein P-II 2 |
Protein Synonyms/Alias | |
Gene Name | glnK |
Gene Synonyms/Alias | ybaI; OrderedLocusNames=b0450, JW0440 |
Created Date | 3-June-2014 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Phosphorylation | Position | Peptide | Code | Type | References | | 51 | ELYRGAEYSVNFLPK | Y | HTP | [1] | |
Reference | [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A PLoS Pathog. 2013;9(6):e1003403. [ PMID:23785281] |
Functional Description From UniProt | FUNCTION: P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity) |
| MOD_RES 51 51 O-UMP-tyrosine (By similarity) |
| 3D-structure; Completeproteome; Nucleotide-binding; Referenceproteome; Transcription; Transcriptionregulation |
Protein Sequence | MKLVTVIIKP FKLEDVREAL SSIGIQGLTV TEVKGFGRQK GHAELYRGAE YSVNFLPKVK 60
IDVAIADDQL DEVIDIVSKA AYTGKIGDGK IFVAELQRVI RIRTGEADEA AL 112 |
| GO:0030234 F:enzyme regulator activity IEA:InterPro GO:0042802 F:identical protein binding IPI:IntAct GO:0000166 F:nucleotide binding IEA:UniProtKB-KW GO:0045848 P:positive regulation of nitrogen utilization IMP:EcoCyc GO:0006355 P:regulation of transcription, DNA-templated IEA:UniProtKB-KW GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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