※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarate reductase iron-sulfur subunit
Protein Synonyms/Alias
 
Gene Name
 frdB
Gene Synonyms/Alias
 b4153, JW4114
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
210 WSCTFVGYCSEVCPK Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
Sequence Annotation From UniProt
 
Key Word From UniProt
 2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Completeproteome; Electrontransport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Referenceproteome; Transport; Tricarboxylicacidcycle
Protein Sequence
 MAEMKNLKIE VVRYNPEVDT APHSAFYEVP YDATTSLLDA LGYIKDNLAP DLSYRWSCRM 60
 AICGSCGMMV NNVPKLACKT FLRDYTDGMK VEALANFPIE RDLVVDMTHF IESLEAIKPY 120
 IIGNSRTADQ GTNIQTPAQM AKYHQFSGCI NCGLCYAACP QFGLNPEFIG PAAITLAHRY 180
 NEDSRDHGKK ERMAQLNSQN GVWSCTFVGY CSEVCPKHVD PAAAIQQGKV ESSKDFLIAT 240
 LKPR 244
  GO:0005737   C:cytoplasm IDA:EcoCyc
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0051537   F:2 iron, 2 sulfur cluster binding IDA:EcoCyc
  GO:0051538   F:3 iron, 4 sulfur cluster binding IDA:EcoCyc
  GO:0051539   F:4 iron, 4 sulfur cluster binding IDA:EcoCyc
  GO:0009055   F:electron carrier activity IDA:EcoCyc
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0008177   F:succinate dehydrogenase (ubiquinone) activity IEA:UniProtKB-EC
  GO:0009061   P:anaerobic respiration IMP:EcoCyc
  GO:0044780   P:bacterial-type flagellum assembly IMP:EcoCyc
  GO:0001539   P:cilium or flagellum-dependent cell motility IMP:EcoCyc
  GO:0006113   P:fermentation IMP:EcoCyc
  GO:0006099   P:tricarboxylic acid cycle IEA:UniProtKB-KW
  IPR001041   2Fe-2S_ferredoxin-type.
  IPR006058   2Fe2S_fd_BS.
  IPR017896   4Fe4S_Fe-S-bd.
  IPR017900   4Fe4S_Fe_S_CS.
  IPR012675   Beta-grasp_dom.
  IPR009051   Helical_ferredxn.
  IPR004489   Succ_DH/fum_Rdtase_Fe-S.
  IPR025192   Succ_DH/fum_Rdtase_N.
  PF13085   Fer2_3.
  PF13183   Fer4_8.
  PS00197   2FE2S_FER_1.
  PS51085   2FE2S_FER_2.
  PS00198   4FE4S_FER_1.
  PS51379   4FE4S_FER_2.