※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarate hydratase class I, aerobic
Protein Synonyms/Alias
 Fumarase
Gene Name
 fumA
Gene Synonyms/Alias
 b1612, JW1604
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
253 KLASAKYYDELPTEG Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically
Sequence Annotation From UniProt
 
Key Word From UniProt
 4Fe-4S; Completeproteome; Directproteinsequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Referenceproteome; Tricarboxylicacidcycle
Protein Sequence
 MSNKPFHYQA PFPLKKDDTE YYLLTSEHVS VSEFEGQEIL KVAPEALTLL ARQAFHDASF 60
 MLRPAHQQQV ADILRDPEAS ENDKYVALQF LRNSDIAAKG VLPTCQDTGT AIIVGKKGQR 120
 VWTGGGDEAA LARGVYNTYI EDNLRYSQNA PLDMYKEVNT GTNLPAQIDL YAVDGDEYKF 180
 LCIAKGGGSA NKTYLYQETK ALLTPGKLKN YLVEKMRTLG TAACPPYHIA FVIGGTSAET 240
 NLKTVKLASA KYYDELPTEG NEHGQAFRDV ELEKELLIEA QNLGLGAQFG GKYFAHDIRV 300
 IRLPRHGASC PVGMGVSCSA DRNIKAKINR QGIWIEKLEH NPGKYIPEEL RKAGEGEAVR 360
 VDLNRPMKEI LAQLSQYPVS TRLSLNGTII VGRDIAHAKL KERMDNGEGL PQYIKDHPIY 420
 YAGPAKTPEG YASGSLGPTT AGRMDSYVDQ LQAQGGSMIM LAKGNRSQQV TDACKKHGGF 480
 YLGSIGGPAA VLAQGSIKSL ECVEYPELGM EAIWKIEVED FPAFILVDDK GNDFFQQIQL 540
 TQCTRCVK 548
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0051539   F:4 iron, 4 sulfur cluster binding IDA:EcoCyc
  GO:0004333   F:fumarate hydratase activity IDA:EcoCyc
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0050163   F:oxaloacetate tautomerase activity IDA:EcoCyc
  GO:0006099   P:tricarboxylic acid cycle IMP:EcoCyc
  IPR004646   Fe-S_hydro-lyase_TtdA-typ_cat.
  IPR004647   Fe-S_hydro-lyase_TtdB-typ_cat.
  IPR011167   Fe_dep_fumarate_hydratase.
  IPR020557   Fumarate_lyase_CS.
  PF05681   Fumerase.
  PF05683   Fumerase_C.
  PS00163   FUMARATE_LYASES.