※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA protection during starvation protein
Protein Synonyms/Alias
 
Gene Name
 dps
Gene Synonyms/Alias
 Z1034, ECs0890
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
16 SKATNLLYTRNDVSD Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Cytoplasm; DNAcondensation; DNA-binding; Iron; Ironstorage; Metal-binding; Oxidoreductase
Protein Sequence
 MSTAKLVKSK ATNLLYTRND VSDSEKKATV ELLNRQVIQF IDLSLITKQA HWNMRGANFI 60
 AVHEMLDGFR TALIDHLDTM AERAVQLGGV ALGTTQVINS KTPLKSYPLD IHNVQDHLKE 120
 LADRYAIVAN DVRKAIGEAK DDDTADILTA ASRDLDKFLW FIESNIE 167
  GO:0005737   C:cytoplasm IEA:UniProtKB-HAMAP
  GO:0009295   C:nucleoid IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-HAMAP
  GO:0008199   F:ferric iron binding IEA:UniProtKB-HAMAP
  GO:0016722   F:oxidoreductase activity, oxidizing metal ions IEA:InterPro
  GO:0006879   P:cellular iron ion homeostasis IEA:UniProtKB-KW
  GO:0030261   P:chromosome condensation IEA:UniProtKB-KW
  GO:0006950   P:response to stress IEA:InterPro
  IPR002177   DPS_DNA-bd.
  IPR023188   DPS_DNA-bd_CS.
  IPR023067   Dps_gammaproteobac.
  IPR009078   Ferritin-like_SF.
  IPR012347   Ferritin-rel.
  IPR008331   Ferritin_DPS_dom.
  PF00210   Ferritin.
  PS00818   DPS_1.
  PS00819   DPS_2.
  PR01346   HELNAPAPROT.