UniProt Accession

 DPS_ECOLI;  P0ABT2;  P27430

Genbank Protein ID

 X69337;  U04242;  U00096;  AP009048;  X14180

Genbank Nucleotide ID

 CAA49169.1;  AAA21855.1;  AAC73899.1;  BAA35484.1

Protein Name

 DNA protection during starvation protein

Protein Synonyms/Alias

 

Gene Name

 dps

Gene Synonyms/Alias

 pexB, vtm; OrderedLocusNames=b0812, JW0797

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [3]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; DNAcondensation; DNA-binding; Iron; Ironstorage; Metal-binding; Oxidoreductase; Referenceproteome

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-HAMAP
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0009295   C:nucleoid IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IDA:EcoCyc
  GO:0008199   F:ferric iron binding IEA:UniProtKB-HAMAP
  GO:0016722   F:oxidoreductase activity, oxidizing metal ions IEA:InterPro
  GO:0006879   P:cellular iron ion homeostasis IEA:UniProtKB-KW
  GO:0030261   P:chromosome condensation IEA:UniProtKB-KW
  GO:0042594   P:response to starvation IDA:EcoCyc

  IPR002177   DPS_DNA-bd.
  IPR023188   DPS_DNA-bd_CS.
  IPR023067   Dps_gammaproteobac.
  IPR009078   Ferritin-like_SF.
  IPR012347   Ferritin-rel.
  IPR008331   Ferritin_DPS_dom.

  PF00210   Ferritin.

  PS00818   DPS_1.
  PS00819   DPS_2.

  PR01346   HELNAPAPROT.