※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylosuccinate lyase
Protein Synonyms/Alias
 ASL;  ASase
Gene Name
 purB
Gene Synonyms/Alias
 b1131, JW1117
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
296 IAGEIGSSTMPHKVN S HTP [1]
146 RDEVILPYWRQLIDG Y HTP [2]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [2]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 
Sequence Annotation From UniProt
 MOD_RES 94 94 N6-acetyllysine
 MOD_RES 366 366 N6-acetyllysine
Key Word From UniProt
 3D-structure; Acetylation; Completeproteome; Directproteinsequencing; Lyase; Purinebiosynthesis; Referenceproteome
Protein Sequence
 MELSSLTAVS PVDGRYGDKV SALRGIFSEY GLLKFRVQVE VRWLQKLAAH AAIKEVPAFA 60
 ADAIGYLDAI VASFSEEDAA RIKTIERTTN HDVKAVEYFL KEKVAEIPEL HAVSEFIHFA 120
 CTSEDINNLS HALMLKTARD EVILPYWRQL IDGIKDLAVQ YRDIPLLSRT HGQPATPSTI 180
 GKEMANVAYR MERQYRQLNQ VEILGKINGA VGNYNAHIAA YPEVDWHQFS EEFVTSLGIQ 240
 WNPYTTQIEP HDYIAELFDC VARFNTILID FDRDVWGYIA LNHFKQKTIA GEIGSSTMPH 300
 KVNPIDFENS EGNLGLSNAV LQHLASKLPV SRWQRDLTDS TVLRNLGVGI GYALIAYQST 360
 LKGVSKLEVN RDHLLDELDH NWEVLAEPIQ TVMRRYGIEK PYEKLKELTR GKRVDAEGMK 420
 QFIDGLALPE EEKARLKAMT PANYIGRAIT MVDELK 456
  GO:0070626   F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity IEA:UniProtKB-EC
  GO:0004018   F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA:EcoCyc
  GO:0044208   P:'de novo' AMP biosynthetic process IEA:UniProtKB-UniPathway
  GO:0006189   P:'de novo' IMP biosynthetic process IEA:UniProtKB-UniPathway
  GO:0006974   P:cellular response to DNA damage stimulus IEP:EcoliWiki
  IPR024083   Fumarase/histidase_N.
  IPR020557   Fumarate_lyase_CS.
  IPR000362   Fumarate_lyase_fam.
  IPR022761   Fumarate_lyase_N.
  IPR008948   L-Aspartase-like.
  IPR004769   Pur_lyase.
  IPR013539   PurB_C.
  PF08328   ASL_C.
  PF00206   Lyase_1.
  PS00163   FUMARATE_LYASES.
  PR00149   FUMRATELYASE.