UniProt Accession

 PTHP_ECO57;  P0AA06;  P05525;  P07006

Genbank Protein ID

 AE005174;  BA000007

Genbank Nucleotide ID

 AAG57534.1;  BAB36710.1

Protein Name

 Phosphocarrier protein HPr

Protein Synonyms/Alias

 

Gene Name

 ptsH

Gene Synonyms/Alias

 Z3681, ECs3287

Created Date

 3-June-2014

Organism

 Escherichia coli O157:H7

NCBI Taxa ID

 83334

Phosphorylation

Reference

 [1]The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH.
 Parche S,Schmid R,Titgemeyer F
 Eur. J. Biochem. 1999, Oct, 1;265(1):308-17. [PMID:10491187]

Functional Description From UniProt

 FUNCTION: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III) (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; Cytoplasm; Kinase; Phosphotransferasesystem; Serine/threonine-proteinkinase; Sugartransport; Transferase; Transport

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IEA:UniProtKB-KW

  IPR000032   HPr_prot-like.
  IPR001020   PTS_HPr_His_P_site.
  IPR002114   PTS_HPr_Ser_P_site.

  PF00381   PTS-HPr.

  PS51350   PTS_HPR_DOM.
  PS00369   PTS_HPR_HIS.
  PS00589   PTS_HPR_SER.

  PR00107   PHOSPHOCPHPR.