UniProt Accession

 PTHP_ECOLI;  P0AA04;  P05525;  P07006

Genbank Protein ID

 M10425;  J02796;  M21994;  M21451;  U00096;  AP009048

Genbank Nucleotide ID

 AAA24438.1;  AAA24440.1;  AAA24384.1;  AAA23655.1;  AAC75468.1;  BAA16289.1

Protein Name

 Phosphocarrier protein HPr

Protein Synonyms/Alias

 

Gene Name

 ptsH

Gene Synonyms/Alias

 hpr; OrderedLocusNames=b2415, JW2408

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Reconstitution studies using the helical and carboxy-terminal domains of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system.
 Zhu PP,Szczepanowski RH,Nosworthy NJ,Ginsburg A,Peterkofsky A
 Biochemistry 1999, Nov, 23;38(47):15470-9. [PMID:10569929]
 [2]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [3]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]

Functional Description From UniProt

 FUNCTION: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; Kinase; Phosphotransferasesystem; Referenceproteome; Serine/threonine-proteinkinase; Sugartransport; Transferase; Transport

Protein Sequence

  GO:0019197   C:phosphoenolpyruvate-dependent sugar phosphotransferase complex IDA:EcoCyc
  GO:0008047   F:enzyme activator activity IDA:EcoliWiki
  GO:0016301   F:kinase activity IDA:EcoCyc
  GO:0008965   F:phosphoenolpyruvate-protein phosphotransferase activity IDA:EcoCyc
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IDA:EcoCyc
  GO:0043085   P:positive regulation of catalytic activity IDA:GOC
  GO:0045819   P:positive regulation of glycogen catabolic process IDA:EcoCyc

  IPR000032   HPr_prot-like.
  IPR001020   PTS_HPr_His_P_site.
  IPR002114   PTS_HPr_Ser_P_site.

  PF00381   PTS-HPr.

  PS51350   PTS_HPR_DOM.
  PS00369   PTS_HPR_HIS.
  PS00589   PTS_HPR_SER.

  PR00107   PHOSPHOCPHPR.