UniProt Accession

 GLNB_ECO57;  P0A9Z3;  P05826

Genbank Protein ID

 AE005174;  BA000007

Genbank Nucleotide ID

 AAG57667.1;  BAB36842.1

Protein Name

 Nitrogen regulatory protein P-II 1

Protein Synonyms/Alias

 

Gene Name

 glnB

Gene Synonyms/Alias

 Z3829, ECs3419

Created Date

 3-June-2014

Organism

 Escherichia coli O157:H7

NCBI Taxa ID

 83334

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity)

Sequence Annotation From UniProt

 MOD_RES 51 51 O-UMP-tyrosine (By similarity)

Key Word From UniProt

 Completeproteome; Nucleotide-binding; Transcription; Transcriptionregulation

Protein Sequence

  GO:0030234   F:enzyme regulator activity IEA:InterPro
  GO:0000166   F:nucleotide binding IEA:UniProtKB-KW
  GO:0006808   P:regulation of nitrogen utilization IEA:InterPro
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR002187   N-reg_PII.
  IPR011322   N-reg_PII-like_a/b.
  IPR015867   N-reg_PII/ATP_PRibTrfase_C.
  IPR017918   N-reg_PII_CS.
  IPR002332   N-reg_PII_urydylation_site.

  PF00543   P-II.

  SM00938   P-II.

  PS00638   PII_GLNB_CTER.
  PS51343   PII_GLNB_DOM.
  PS00496   PII_GLNB_UMP.

  PR00340   PIIGLNB.