※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aspartate-semialdehyde dehydrogenase
Protein Synonyms/Alias
 ASA dehydrogenase;  ASADH
Gene Name
 asd
Gene Synonyms/Alias
 hom; OrderedLocusNames=b3433, JW3396
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
38 RPVFFSTSQLGQAAP S HTP [1]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 FUNCTION: Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sequence Annotation From UniProt
 MOD_RES 135 135 S-cysteinyl cysteine; in inhibited form
Key Word From UniProt
 3D-structure; Amino-acidbiosynthesis; Completeproteome; Diaminopimelatebiosynthesis; Directproteinsequencing; Lysinebiosynthesis; Methioninebiosynthesis; NADP; Oxidoreductase; Referenceproteome; Threoninebiosynthesis
Protein Sequence
 MKNVGFIGWR GMVGSVLMQR MVEERDFDAI RPVFFSTSQL GQAAPSFGGT TGTLQDAFDL 60
 EALKALDIIV TCQGGDYTNE IYPKLRESGW QGYWIDAASS LRMKDDAIII LDPVNQDVIT 120
 DGLNNGIRTF VGGNCTVSLM LMSLGGLFAN DLVDWVSVAT YQAASGGGAR HMRELLTQMG 180
 HLYGHVADEL ATPSSAILDI ERKVTTLTRS GELPVDNFGV PLAGSLIPWI DKQLDNGQSR 240
 EEWKGQAETN KILNTSSVIP VDGLCVRVGA LRCHSQAFTI KLKKDVSIPT VEELLAAHNP 300
 WAKVVPNDRE ITMRELTPAA VTGTLTTPVG RLRKLNMGPE FLSAFTVGDQ LLWGAAEPLR 360
 RMLRQLA 367
  GO:0005737   C:cytoplasm IEA:InterPro
  GO:0004073   F:aspartate-semialdehyde dehydrogenase activity IDA:EcoCyc
  GO:0003942   F:N-acetyl-gamma-glutamyl-phosphate reductase activity IEA:InterPro
  GO:0051287   F:NAD binding IEA:InterPro
  GO:0050661   F:NADP binding IEA:UniProtKB-HAMAP
  GO:0071266   P:'de novo' L-methionine biosynthetic process IEA:UniProtKB-HAMAP
  GO:0006974   P:cellular response to DNA damage stimulus IEP:EcoliWiki
  GO:0019877   P:diaminopimelate biosynthetic process IEA:UniProtKB-HAMAP
  GO:0009090   P:homoserine biosynthetic process IDA:EcoCyc
  GO:0009097   P:isoleucine biosynthetic process IEA:InterPro
  GO:0009089   P:lysine biosynthetic process via diaminopimelate IDA:EcoCyc
  GO:0009088   P:threonine biosynthetic process IEA:UniProtKB-HAMAP
  IPR000319   Asp-semialdehyde_DH_CS.
  IPR011534   Asp_ADH_gamma-type.
  IPR012080   Asp_semialdehyde_DH.
  IPR016040   NAD(P)-bd_dom.
  IPR000534   Semialdehyde_DH_NAD-bd.
  IPR012280   Semialdhyde_DH_dimer_dom.
  PF01118   Semialdhyde_dh.
  PF02774   Semialdhyde_dhC.
  SM00859   Semialdhyde_dh.
  PS01103   ASD.