※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldehyde-alcohol dehydrogenase
Protein Synonyms/Alias
 ADH;  ACDH;  PFL deactivase
Gene Name
 adhE
Gene Synonyms/Alias
 Z2016, ECs1741
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
766 KQTAFSQYDRPQARR Y HTP [1]
75 KNHFASEYIYNAYKD Y HTP [1]
384 NQPARVSYFGQKMKT Y HTP [1]
80 SEYIYNAYKDEKTCG Y HTP [1]
302 AIVGQPAYKIAELAG Y HTP [1]
203 PGMVKAAYSSGKPAI Y HTP [1]
581 MDIRKRIYKFPKMGV Y HTP [1]
690 KEYLPASYHEGSKNP Y HTP [1]
77 HFASEYIYNAYKDEK Y HTP [1]
409 QGGIGDLYNFKLAPS Y HTP [1]
272 RFATHGGYLLQGKEL Y HTP [1]
372 IGHTSCLYTDQDNQP Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction (By similarity)
Sequence Annotation From UniProt
 MOD_RES 358 358 N6-acetyllysine (By similarity)
Key Word From UniProt
 Acetylation; Completeproteome; Iron; Multifunctionalenzyme; NAD; Oxidoreductase
Protein Sequence
 MAVTNVAELN ALVERVKKAQ REYASFTQEQ VDKIFRAAAL AAADARIPLA KMAVAESGMG 60
 IVEDKVIKNH FASEYIYNAY KDEKTCGVLS EDDTFGTITI AEPIGIICGI VPTTNPTSTA 120
 IFKSLISLKT RNAIIFSPHP RAKDATNKAA DIVLQAAIAA GAPKDLIGWI DQPSVELSNA 180
 LMHHPDINLI LATGGPGMVK AAYSSGKPAI GVGAGNTPVV IDETADIKRA VASVLMSKTF 240
 DNGVICASEQ SVVVVDSVYD AVRERFATHG GYLLQGKELK AVQDVILKNG ALNAAIVGQP 300
 AYKIAELAGF SVPENTKILI GEVTVVDESE PFAHEKLSPT LAMYRAKDFE DAVEKAEKLV 360
 AMGGIGHTSC LYTDQDNQPA RVSYFGQKMK TARILINTPA SQGGIGDLYN FKLAPSLTLG 420
 CGSWGGNSIS ENVGPKHLIN KKTVAKRAEN MLWHKLPKSI YFRRGSLPIA LDEVITDGHK 480
 RALIVTDRFL FNNGYADQIT SVLKAAGVET EVFFEVEADP TLSIVRKGAE LANSFKPDVI 540
 IALGGGSPMD AAKIMWVMYE HPETHFEELA LRFMDIRKRI YKFPKMGVKA KMIAVTTTSG 600
 TGSEVTPFAV VTDDATGQKY PLADYALTPD MAIVDANLVM DMPKSLCAFG GLDAVTHAME 660
 AYVSVLASEF SDGQALQALK LLKEYLPASY HEGSKNPVAR ERVHSAATIA GIAFANAFLG 720
 VCHSMAHKLG SQFHIPHGLA NALLICNVIR YNANDNPTKQ TAFSQYDRPQ ARRRYAEIAD 780
 HLGLSAPGDR TAAKIEKLLA WLETLKAELG IPKSIREAGV QEADFLANVD KLSEDAFDDQ 840
 CTGANPRYPL ISELKQILLD TYYGRDYVEG ETAAKKEAAP AKAEKKAKKS A 891
  GO:0008774   F:acetaldehyde dehydrogenase (acetylating) activity IEA:UniProtKB-EC
  GO:0004022   F:alcohol dehydrogenase (NAD) activity IEA:UniProtKB-EC
  GO:0046872   F:metal ion binding IEA:InterPro
  GO:0006066   P:alcohol metabolic process IEA:InterPro
  GO:0015976   P:carbon utilization IEA:InterPro
  IPR001670   ADH_Fe.
  IPR018211   ADH_Fe_CS.
  IPR016161   Ald_DH/histidinol_DH.
  IPR016163   Ald_DH_C.
  IPR016162   Ald_DH_N.
  IPR015590   Aldehyde_DH_dom.
  IPR012079   Bifunc_Ald/ADH.
  PF00171   Aldedh.
  PF00465   Fe-ADH.
  PS00913   ADH_IRON_1.
  PS00060   ADH_IRON_2.