UniProt Accession

 ARCA_ECOLI;  P0A9Q1;  P03026;  Q2M5R6

Genbank Protein ID

 M10044;  U14003;  U00096;  AP009048;  L34010

Genbank Nucleotide ID

 AAA23718.1;  AAA97297.1;  AAC77354.1;  BAE78390.1;  AAA23476.1

Protein Name

 Aerobic respiration control protein ArcA

Protein Synonyms/Alias

 

Gene Name

 arcA

Gene Synonyms/Alias

 cpxC, dye, fexA, msp, seg, sfrA

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Amplification of signaling activity of the arc two-component system of Escherichia coli by anaerobic metabolites. An in vitro study with different protein modules.
 Georgellis D,Kwon O,Lin EC
 J. Biol. Chem. 1999, Dec, 10;274(50):35950-4. [PMID:10585483]

Functional Description From UniProt

 FUNCTION: Member of the two-component regulatory system ArcB/ArcA Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter

Sequence Annotation From UniProt

 MOD_RES 54 54 4-aspartylphosphate (By similarity)

Key Word From UniProt

 3D-structure; Activator; Completeproteome; Cytoplasm; Directproteinsequencing; DNA-binding; Phosphoprotein; Referenceproteome; Repressor; Transcription; Transcriptionregulation; Two-componentregulatorysystem

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0000156   F:phosphorelay response regulator activity IDA:EcoCyc
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IDA:EcoCyc
  GO:0035556   P:intracellular signal transduction IDA:GOC
  GO:0045892   P:negative regulation of transcription, DNA-templated IDA:EcoCyc
  GO:0000160   P:phosphorelay signal transduction system IDA:EcoCyc
  GO:0045893   P:positive regulation of transcription, DNA-templated IDA:EcoCyc
  GO:0006355   P:regulation of transcription, DNA-templated IDA:EcoCyc
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR011006   CheY-like_superfamily.
  IPR001867   Sig_transdc_resp-reg_C.
  IPR016032   Sig_transdc_resp-reg_C-effctor.
  IPR001789   Sig_transdc_resp-reg_receiver.
  IPR011991   WHTH_DNA-bd_dom.

  PF00072   Response_reg.
  PF00486   Trans_reg_C.

  SM00448   REC.
  SM00862   Trans_reg_C.

  PS50110   RESPONSE_REGULATORY.