※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hypoxanthine phosphoribosyltransferase
Protein Synonyms/Alias
 HPRT
Gene Name
 hpt
Gene Synonyms/Alias
 b0125, JW5009
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
104 IVEDIIDSGNTLSKV S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Cytoplasm; Glycosyltransferase; Magnesium; Metal-binding; Nucleotide-binding; Purinesalvage; Referenceproteome; Transferase
Protein Sequence
 MKHTVEVMIP EAEIKARIAE LGRQITERYK DSGSDMVLVG LLRGSFMFMA DLCREVQVSH 60
 EVDFMTASSY GSGMSTTRDV KILKDLDEDI RGKDVLIVED IIDSGNTLSK VREILSLREP 120
 KSLAICTLLD KPSRREVNVP VEFIGFSIPD EFVVGYGIDY AQRYRHLPYI GKVILLDE 178
  GO:0005829   C:cytosol IBA:RefGenome
  GO:0052657   F:guanine phosphoribosyltransferase activity IEA:UniProtKB-EC
  GO:0004422   F:hypoxanthine phosphoribosyltransferase activity IDA:EcoCyc
  GO:0000287   F:magnesium ion binding IDA:EcoCyc
  GO:0000166   F:nucleotide binding IEA:UniProtKB-KW
  GO:0006168   P:adenine salvage IBA:RefGenome
  GO:0032263   P:GMP salvage IDA:EcoliWiki
  GO:0006178   P:guanine salvage IBA:RefGenome
  GO:0046100   P:hypoxanthine metabolic process IBA:RefGenome
  GO:0032264   P:IMP salvage IDA:EcoliWiki
  GO:0006166   P:purine ribonucleoside salvage IBA:RefGenome
  IPR005904   Hxn_phspho_trans.
  IPR000836   PRibTrfase_dom.
  PF00156   Pribosyltran.
  PS00103   PUR_PYR_PR_TRANSFER.