※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate lyase
Protein Synonyms/Alias
 ICL;  Isocitrase;  Isocitratase
Gene Name
 aceA
Gene Synonyms/Alias
 icl; OrderedLocusNames=b4015, JW3975
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
5 ***MKTRTQQIEELQ T HTP [1]
398 KDGYTFVSHQQEVGT S HTP [1]
3 *****MKTRTQQIEE T HTP [1]
321 LAYNCSPSFNWQKNL S HTP [1]
316 YPGKLLAYNCSPSFN Y HTP [2]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [2]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Cytoplasm; Glyoxylatebypass; Lyase; Phosphoprotein; Referenceproteome; Tricarboxylicacidcycle
Protein Sequence
 MKTRTQQIEE LQKEWTQPRW EGITRPYSAE DVVKLRGSVN PECTLAQLGA AKMWRLLHGE 60
 SKKGYINSLG ALTGGQALQQ AKAGIEAVYL SGWQVAADAN LAASMYPDQS LYPANSVPAV 120
 VERINNTFRR ADQIQWSAGI EPGDPRYVDY FLPIVADAEA GFGGVLNAFE LMKAMIEAGA 180
 AAVHFEDQLA SVKKCGHMGG KVLVPTQEAI QKLVAARLAA DVTGVPTLLV ARTDADAADL 240
 ITSDCDPYDS EFITGERTSE GFFRTHAGIE QAISRGLAYA PYADLVWCET STPDLELARR 300
 FAQAIHAKYP GKLLAYNCSP SFNWQKNLDD KTIASFQQQL SDMGYKFQFI TLAGIHSMWF 360
 NMFDLANAYA QGEGMKHYVE KVQQPEFAAA KDGYTFVSHQ QEVGTGYFDK VTTIIQGGTS 420
 SVTALTGSTE ESQF 434
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0043169   F:cation binding IDA:EcoliWiki
  GO:0004451   F:isocitrate lyase activity IDA:EcoliWiki
  GO:0006097   P:glyoxylate cycle IC:EcoliWiki
  GO:0006099   P:tricarboxylic acid cycle IEA:UniProtKB-KW
  IPR006254   Isocitrate_lyase.
  IPR018523   Isocitrate_lyase_ph_CS.
  IPR015813   Pyrv/PenolPyrv_Kinase-like_dom.
  PF00463   ICL.
  PS00161   ISOCITRATE_LYASE.