UniProt Accession

 FUR_ECO57;  P0A9B1;  P06975

Genbank Protein ID

 AE005174;  BA000007

Genbank Nucleotide ID

 AAG55006.1;  BAB34137.1

Protein Name

 Ferric uptake regulation protein

Protein Synonyms/Alias

 Ferric uptake regulator

Gene Name

 fur

Gene Synonyms/Alias

 Z0831, ECs0714

Created Date

 3-June-2014

Organism

 Escherichia coli O157:H7

NCBI Taxa ID

 83334

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; Cytoplasm; DNA-binding; Iron; Metal-binding; Repressor; Transcription; Transcriptionregulation; Zinc

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR002481   FUR.
  IPR011991   WHTH_DNA-bd_dom.

  PF01475   FUR.