※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thiol peroxidase
Protein Synonyms/Alias
 
Gene Name
 tpx
Gene Synonyms/Alias
 yzzJ; OrderedLocusNames=b1324, JW1317
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
17 NPVTVANSIPQAGSK S HTP [1]
39 AKDLSDVTLGQFAGK T HTP [2]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Has antioxidant activity. Could remove peroxides or H(2)O(2) within the catalase- and peroxidase-deficient periplasmic space
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Antioxidant; Completeproteome; Directproteinsequencing; Oxidoreductase; Periplasm; Peroxidase; Referenceproteome
Protein Sequence
 MSQTVHFQGN PVTVANSIPQ AGSKAQTFTL VAKDLSDVTL GQFAGKRKVL NIFPSIDTGV 60
 CAASVRKFNQ LATEIDNTVV LCISADLPFA QSRFCGAEGL NNVITLSTFR NAEFLQAYGV 120
 AIADGPLKGL AARAVVVIDE NDNVIFSQLV DEITTEPDYE AALAVLKA 168
  GO:0005737   C:cytoplasm IDA:EcoCyc
  GO:0042597   C:periplasmic space IEA:UniProtKB-SubCell
  GO:0032843   F:hydroperoxide reductase activity IDA:EcoCyc
  GO:0008379   F:thioredoxin peroxidase activity IDA:EcoCyc
  GO:0045454   P:cell redox homeostasis IEA:UniProtKB-HAMAP
  GO:0034599   P:cellular response to oxidative stress IMP:EcoCyc
  IPR018219   Antioxidant_Tpx_CS.
  IPR002065   Put_TPX.
  IPR013740   Redoxin.
  IPR012336   Thioredoxin-like_fold.
  PF08534   Redoxin.
  PS51352   THIOREDOXIN_2.
  PS01265   TPX.