※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trigger factor
Protein Synonyms/Alias
 TF
Gene Name
 tig
Gene Synonyms/Alias
 b0436, JW0426
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
288 AIRNRVKSQAIEGLV S HTP [1]
376 GLIEEMASAYEDPKE S HTP [1]
378 IEEMASAYEDPKEVI Y HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Cellcycle; Celldivision; Chaperone; Completeproteome; Cytoplasm; Directproteinsequencing; Isomerase; Referenceproteome; Rotamase
Protein Sequence
 MQVSVETTQG LGRRVTITIA ADSIETAVKS ELVNVAKKVR IDGFRKGKVP MNIVAQRYGA 60
 SVRQDVLGDL MSRNFIDAII KEKINPAGAP TYVPGEYKLG EDFTYSVEFE VYPEVELQGL 120
 EAIEVEKPIV EVTDADVDGM LDTLRKQQAT WKEKDGAVEA EDRVTIDFTG SVDGEEFEGG 180
 KASDFVLAMG QGRMIPGFED GIKGHKAGEE FTIDVTFPEE YHAENLKGKA AKFAINLKKV 240
 EERELPELTA EFIKRFGVED GSVEGLRAEV RKNMERELKS AIRNRVKSQA IEGLVKANDI 300
 DVPAALIDSE IDVLRRQAAQ RFGGNEKQAL ELPRELFEEQ AKRRVVVGLL LGEVIRTNEL 360
 KADEERVKGL IEEMASAYED PKEVIEFYSK NKELMDNMRN VALEEQAVEA VLAKAKVTEK 420
 ETTFNELMNQ QA 432
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0003755   F:peptidyl-prolyl cis-trans isomerase activity IDA:EcoCyc
  GO:0044183   F:protein binding involved in protein folding IDA:EcoCyc
  GO:0043022   F:ribosome binding IDA:EcoCyc
  GO:0051083   P:'de novo' cotranslational protein folding IDA:EcoCyc
  GO:0007049   P:cell cycle IEA:UniProtKB-KW
  GO:0051301   P:cell division IEA:UniProtKB-KW
  GO:0000413   P:protein peptidyl-prolyl isomerization IDA:GOC
  GO:0015031   P:protein transport IEA:UniProtKB-HAMAP
  IPR001179   PPIase_FKBP_dom.
  IPR005215   Trig_fac.
  IPR008880   Trigger_fac_C.
  IPR008881   Trigger_fac_ribosome-bd_bac.
  IPR027304   Trigger_fact/SurA_dom.
  PF00254   FKBP_C.
  PF05698   Trigger_C.
  PF05697   Trigger_N.
  PS50059   FKBP_PPIASE.