※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinyl-CoA ligase [ADP-forming] subunit beta
Protein Synonyms/Alias
 SCS-beta
Gene Name
 sucC
Gene Synonyms/Alias
 Z0882, ECs0753
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
84 LGKRLVTYQTDANGQ Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: During aerobic metabolism it functions in the citric acid cycle, coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents an important site of substrate-level phosphorylation. It can also function in the other direction for anabolic purposes, and this may be particularly important for providing succinyl-CoA during anaerobic growth when the oxidative route from 2-oxoglutarate is severely repressed. The beta-subunit contains the attachment sites for succinate. The complete active site is probably located in the region of alpha- beta contact (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 ATP-binding; Completeproteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Tricarboxylicacidcycle
Protein Sequence
 MNLHEYQAKQ LFARYGLPAP VGYACTTPRE AEEAASKIGA GPWVVKCQVH AGGRGKAGGV 60
 KVVNSKEDIR AFAENWLGKR LVTYQTDANG QPVNQILVEA ATDIAKELYL GAVVDRSSRR 120
 VVFMASTEGG VEIEKVAEET PHLIHKVALD PLTGPMPYQG RELAFKLGLE GKLVQQFTKI 180
 FMGLATIFLE RDLALIEINP LVITKQGDLI CLDGKLGADG NALFRQPDLR EMRDQSQEDP 240
 REAQAAQWEL NYVALDGNIG CMVNGAGLAM GTMDIVKLHG GEPANFLDVG GGATKERVTE 300
 AFKIILSDDK VKAVLVNIFG GIVRCDLIAD GIIGAVAEVG VNVPVVVRLE GNNAELGAKK 360
 LADSGLNIIA AKGLTDAAQQ VVAAVEGK 388
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0030145   F:manganese ion binding IEA:UniProtKB-HAMAP
  GO:0004775   F:succinate-CoA ligase (ADP-forming) activity IEA:UniProtKB-HAMAP
  GO:0006099   P:tricarboxylic acid cycle IEA:UniProtKB-HAMAP
  IPR011761   ATP-grasp.
  IPR013650   ATP-grasp_succ-CoA_synth-type.
  IPR013815   ATP_grasp_subdomain_1.
  IPR013816   ATP_grasp_subdomain_2.
  IPR005811   CoA_ligase.
  IPR017866   Succ-CoA_synthase_bsu_CS.
  IPR005809   Succ_CoA_synthase_bsu.
  IPR016102   Succinyl-CoA_synth-like.
  PF08442   ATP-grasp_2.
  PF00549   Ligase_CoA.
  PS50975   ATP_GRASP.
  PS01217   SUCCINYL_COA_LIG_3.