UniProt Accession

 RL1_ECOLI;  P0A7L0;  P02384;  Q2M8S0

Genbank Protein ID

 V00339;  U00006;  U00096;  AP009048

Genbank Nucleotide ID

 CAA23622.1;  AAC43082.1;  AAC76958.1;  BAE77336.1

Protein Name

 50S ribosomal protein L1

Protein Synonyms/Alias

 

Gene Name

 rplA

Gene Synonyms/Alias

 b3984, JW3947

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Comprehensive analysis of phosphorylated proteins of Escherichia coli ribosomes.
 Soung GY,Miller JL,Koc H,Koc EC
 J. Proteome Res. 2009, Jul;8(7):3390-402. [PMID:19469554]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]

Functional Description From UniProt

 FUNCTION: One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms (PubMed:12859903). This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation (PubMed:12859903). Contacts the P and E site tRNAs

Sequence Annotation From UniProt

 MOD_RES 105 105 N6-succinyllysine
 MOD_RES 154 154 N6-succinyllysine
 MOD_RES 186 186 N6-succinyllysine
 MOD_RES 197 197 N6-succinyllysine

Key Word From UniProt

 3D-structure; Completeproteome; Directproteinsequencing; Referenceproteome; Repressor; Ribonucleoprotein; Ribosomalprotein; RNA-binding; rRNA-binding; Translationregulation; tRNA-binding

Protein Sequence

  GO:0022625   C:cytosolic large ribosomal subunit IDA:EcoCyc
  GO:0019843   F:rRNA binding IEA:UniProtKB-HAMAP
  GO:0003735   F:structural constituent of ribosome IEA:InterPro
  GO:0000049   F:tRNA binding IEA:UniProtKB-KW
  GO:0045947   P:negative regulation of translational initiation IDA:EcoCyc
  GO:0006412   P:translation IEA:UniProtKB-HAMAP

  IPR005878   Ribosom_L1_bac-type.
  IPR002143   Ribosomal_L1.
  IPR023674   Ribosomal_L1-like.
  IPR028364   Ribosomal_L1/biogenesis.
  IPR016094   Ribosomal_L1_2-a/b-sand.
  IPR016095   Ribosomal_L1_3-a/b-sand.
  IPR023673   Ribosomal_L1_CS.

  PF00687   Ribosomal_L1.

  PS01199   RIBOSOMAL_L1.