UniProt Accession

 RL19_ECOLI;  P0A7K6;  P02420

Genbank Protein ID

 X01818;  U00096;  AP009048

Genbank Nucleotide ID

 CAA25960.1;  AAC75655.1;  BAA16491.1

Protein Name

 50S ribosomal protein L19

Protein Synonyms/Alias

 

Gene Name

 rplS

Gene Synonyms/Alias

 b2606, JW2587

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]

Functional Description From UniProt

 FUNCTION: This protein is located at the 30S-50S ribosomal subunit interface. In the 70S ribosome (PubMed:12809609) it has been modeled to make two contacts with the 16S rRNA of the 30S subunit forming part of bridges B6 and B8. In the 3.5 A resolved structures (PubMed:16272117) L14 and L19 interact and together make contact with the 16S rRNA. The protein conformation is quite different between the 50S and 70S structures, which may be necessary for translocation

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Completeproteome; Directproteinsequencing; Referenceproteome; Ribonucleoprotein; Ribosomalprotein; RNA-binding; rRNA-binding

Protein Sequence

  GO:0022625   C:cytosolic large ribosomal subunit IDA:EcoCyc
  GO:0019843   F:rRNA binding IEA:UniProtKB-KW
  GO:0003735   F:structural constituent of ribosome IEA:InterPro
  GO:0006412   P:translation IEA:UniProtKB-HAMAP

  IPR001857   Ribosomal_L19.
  IPR018257   Ribosomal_L19_CS.
  IPR008991   Translation_prot_SH3-like.

  PF01245   Ribosomal_L19.

  PS01015   RIBOSOMAL_L19.

  PR00061   RIBOSOMALL19.