UniProt Accession

 RL7_ECOLI;  P0A7K2;  P02392;  Q2M8S2

Genbank Protein ID

 V00339;  M38301;  U00006;  U00096;  AP009048

Genbank Nucleotide ID

 CAA23624.1;  AAA24573.1;  AAC43084.1;  AAC76960.1;  BAE77334.1

Protein Name

 50S ribosomal protein L7/L12

Protein Synonyms/Alias

 

Gene Name

 rplL

Gene Synonyms/Alias

 b3986, JW3949

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]

Functional Description From UniProt

 FUNCTION: The binding site for several of the GTPase factors involved in protein synthesis (IF-2, EF-Tu, EF-G and RF3). Is thus essential for accurate translation. Deletion of 1 of the L12 dimers from the ribosome (by deleting the binding site on L10) leads to decreased IF-2 association with the 70S ribosome and decreased stimulation of the GTPase activity of EF-G

Sequence Annotation From UniProt

 MOD_RES 2 2 N-acetylserine; in L7
 MOD_RES 82 82 N6-methyllysine; partial

Key Word From UniProt

 3D-structure; Acetylation; Completeproteome; Directproteinsequencing; Methylation; Referenceproteome; Ribonucleoprotein; Ribosomalprotein

Protein Sequence

  GO:0022625   C:cytosolic large ribosomal subunit IDA:EcoCyc
  GO:0003735   F:structural constituent of ribosome IEA:InterPro
  GO:0006412   P:translation IEA:UniProtKB-HAMAP

  IPR000206   Ribosomal_L7/12.
  IPR014719   Ribosomal_L7/12_C/ClpS-like.
  IPR013823   Ribosomal_L7/L12_C.
  IPR008932   Ribosomal_L7/L12_oligo.

  PF00542   Ribosomal_L12.