※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylosuccinate synthetase
Protein Synonyms/Alias
 AMPSase;  AdSS
Gene Name
 purA
Gene Synonyms/Alias
 adeK; OrderedLocusNames=b4177, JW4135
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
390 TFGVKDRSGLPQAAL S HTP [1]
382 TMPGWSESTFGVKDR S HTP [1]
129 RGAKAIGTTGRGIGP T HTP [1]
380 YETMPGWSESTFGVK S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; GTP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Purinebiosynthesis; Referenceproteome
Protein Sequence
 MGNNVVVLGT QWGDEGKGKI VDLLTERAKY VVRYQGGHNA GHTLVINGEK TVLHLIPSGI 60
 LRENVTSIIG NGVVLSPAAL MKEMKELEDR GIPVRERLLL SEACPLILDY HVALDNAREK 120
 ARGAKAIGTT GRGIGPAYED KVARRGLRVG DLFDKETFAE KLKEVMEYHN FQLVNYYKAE 180
 AVDYQKVLDD TMAVADILTS MVVDVSDLLD QARQRGDFVM FEGAQGTLLD IDHGTYPYVT 240
 SSNTTAGGVA TGSGLGPRYV DYVLGILKAY STRVGAGPFP TELFDETGEF LCKQGNEFGA 300
 TTGRRRRTGW LDTVAVRRAV QLNSLSGFCL TKLDVLDGLK EVKLCVAYRM PDGREVTTTP 360
 LAADDWKGVE PIYETMPGWS ESTFGVKDRS GLPQAALNYI KRIEELTGVP IDIISTGPDR 420
 TETMILRDPF DA 432
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0004019   F:adenylosuccinate synthase activity IDA:EcoCyc
  GO:0005525   F:GTP binding IEA:UniProtKB-HAMAP
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0044208   P:'de novo' AMP biosynthetic process IEA:UniProtKB-UniPathway
  GO:0046086   P:adenosine biosynthetic process IMP:EcoliWiki
  GO:0006974   P:cellular response to DNA damage stimulus IEP:EcoliWiki
  GO:0015949   P:nucleobase-containing small molecule interconversion IDA:EcoliWiki
  GO:0006164   P:purine nucleotide biosynthetic process IMP:EcoCyc
  IPR018220   Adenylosuccinate_synthase_AS.
  IPR001114   Adenylosuccinate_synthetase.
  IPR027417   P-loop_NTPase.
  PF00709   Adenylsucc_synt.
  SM00788   Adenylsucc_synt.
  PS01266   ADENYLOSUCCIN_SYN_1.
  PS00513   ADENYLOSUCCIN_SYN_2.