※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoside diphosphate kinase
Protein Synonyms/Alias
 NDK;  NDP kinase
Gene Name
 ndk
Gene Synonyms/Alias
 b2518, JW2502
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
93 HRDLLGATNPANALA T HTP [1]
107 AGTLRADYADSLTEN Y HTP [2]
121 NGTHGSDSVESAARE S LTP [3],UniProt
119 TENGTHGSDSVESAA S LTP [3],UniProt
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [2]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
 [3]Identification of phosphoproteins in Escherichia coli.
 Freestone P,Grant S,Toth I,Norris V
 Mol. Microbiol. 1995, Feb;15(3):573-80. [PMID:7783627]
Functional Description From UniProt
 FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Sequence Annotation From UniProt
 MOD_RES 119 119 Phosphoserine
 MOD_RES 121 121 Phosphoserine
Key Word From UniProt
 3D-structure; ATP-binding; Completeproteome; Cytoplasm; Directproteinsequencing; Kinase; Magnesium; Metal-binding; Nucleotidemetabolism; Nucleotide-binding; Phosphoprotein; Referenceproteome; Transferase
Protein Sequence
 MAIERTFSII KPNAVAKNVI GNIFARFEAA GFKIVGTKML HLTVEQARGF YAEHDGKPFF 60
 DGLVEFMTSG PIVVSVLEGE NAVQRHRDLL GATNPANALA GTLRADYADS LTENGTHGSD 120
 SVESAAREIA YFFGEGEVCP RTR 143
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0004550   F:nucleoside diphosphate kinase activity IDA:EcoCyc
  GO:0006241   P:CTP biosynthetic process IEA:UniProtKB-HAMAP
  GO:0006183   P:GTP biosynthetic process IEA:UniProtKB-HAMAP
  GO:0006228   P:UTP biosynthetic process IEA:UniProtKB-HAMAP
  IPR001564   Nucleoside_diP_kinase.
  IPR023005   Nucleoside_diP_kinase_AS.
  PF00334   NDK.
  SM00562   NDK.
  PS00469   NDP_KINASES.
  PR01243   NUCDPKINASE.