| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA-binding protein Hfq |
Protein Synonyms/Alias | HF-I |
Gene Name | hfq |
Gene Synonyms/Alias | b4172, JW4130 |
Created Date | 3-June-2014 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Phosphorylation | Position | Peptide | Code | Type | References | | 49 | FVILLKNTVSQMVYK | T | HTP | [1] | |
Reference | [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium. Soares NC,Spät P,Krug K,Macek B J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [ PMID:23590516] |
Functional Description From UniProt | FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication |
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| 3D-structure; Completeproteome; Directproteinsequencing; DNA-binding; Referenceproteome; RNA-binding; Stressresponse |
Protein Sequence | MAKGQSLQDP FLNALRRERV PVSIYLVNGI KLQGQIESFD QFVILLKNTV SQMVYKHAIS 60
TVVPSRPVSH HSNNAGGGTS SNYHHGSSAQ NTSAQQDSEE TE 102 |
| GO:0003681 F:bent DNA binding IDA:EcoliWiki GO:0003723 F:RNA binding IDA:EcoCyc GO:0040033 P:negative regulation of translation, ncRNA-mediated IEP:EcoliWiki GO:0045975 P:positive regulation of translation, ncRNA-mediated IMP:EcoCyc GO:0006355 P:regulation of transcription, DNA-templated IEA:InterPro GO:0006950 P:response to stress IEA:UniProtKB-KW |
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