UniProt Accession

 GREA_ECO57;  P0A6W7;  P21346;  P78111;  Q8X9K9

Genbank Protein ID

 AE005174;  BA000007

Genbank Nucleotide ID

 AAG58315.1;  BAB37483.1

Protein Name

 Transcription elongation factor GreA

Protein Synonyms/Alias

 

Gene Name

 greA

Gene Synonyms/Alias

 Z4543, ECs4060

Created Date

 3-June-2014

Organism

 Escherichia coli O157:H7

NCBI Taxa ID

 83334

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; DNA-binding; Transcription; Transcriptionregulation

Protein Sequence

  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0032784   P:regulation of DNA-templated transcription, elongation IEA:InterPro
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR018151   TF_GreA/GreB_CS.
  IPR006359   Tscrpt_elong_fac_GreA.
  IPR028624   Tscrpt_elong_fac_GreA/B.
  IPR001437   Tscrpt_elong_fac_GreA/B_C.
  IPR023459   Tscrpt_elong_fac_GreA/B_fam.
  IPR022691   Tscrpt_elong_fac_GreA/B_N.

  PF01272   GreA_GreB.
  PF03449   GreA_GreB_N.

  PS00829   GREAB_1.
  PS00830   GREAB_2.