※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent Clp protease ATP-binding subunit ClpX
Protein Synonyms/Alias
 
Gene Name
 clpX
Gene Synonyms/Alias
 lopC; OrderedLocusNames=b0438, JW0428
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
422 KPEAQQASGE***** S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: ATP-dependent specificity component of the Clp protease Uses cycles of ATP binding and hydrolysis to unfold proteins and translocate them to the ClpP protease. It directs the protease to specific substrates both with and without the help of adapter proteins such as SspB. Participates in the final steps of RseA- sigma-E degradation, liberating sigma-E to induce the extracytoplasmic-stress response. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; ATP-binding; Chaperone; Completeproteome; Directproteinsequencing; Host-virusinteraction; Metal-binding; Nucleotide-binding; Referenceproteome; Stressresponse; Zinc; Zinc-finger
Protein Sequence
 MTDKRKDGSG KLLYCSFCGK SQHEVRKLIA GPSVYICDEC VDLCNDIIRE EIKEVAPHRE 60
 RSALPTPHEI RNHLDDYVIG QEQAKKVLAV AVYNHYKRLR NGDTSNGVEL GKSNILLIGP 120
 TGSGKTLLAE TLARLLDVPF TMADATTLTE AGYVGEDVEN IIQKLLQKCD YDVQKAQRGI 180
 VYIDEIDKIS RKSDNPSITR DVSGEGVQQA LLKLIEGTVA AVPPQGGRKH PQQEFLQVDT 240
 SKILFICGGA FAGLDKVISH RVETGSGIGF GATVKAKSDK ASEGELLAQV EPEDLIKFGL 300
 IPEFIGRLPV VATLNELSEE ALIQILKEPK NALTKQYQAL FNLEGVDLEF RDEALDAIAK 360
 KAMARKTGAR GLRSIVEAAL LDTMYDLPSM EDVEKVVIDE SVIDGQSKPL LIYGKPEAQQ 420
 ASGE 424
  GO:0005524   F:ATP binding IDA:EcoCyc
  GO:0004176   F:ATP-dependent peptidase activity IDA:CACAO
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0008270   F:zinc ion binding IEA:InterPro
  GO:0006200   P:ATP catabolic process IDA:GOC
  GO:0051301   P:cell division IGI:CACAO
  GO:0006457   P:protein folding IEA:UniProtKB-HAMAP
  GO:0006508   P:proteolysis IDA:GOC
  GO:0006950   P:response to stress IEA:UniProtKB-KW
  IPR003593   AAA+_ATPase.
  IPR003959   ATPase_AAA_core.
  IPR019489   Clp_ATPase_C.
  IPR004487   Clp_protease_ATP-bd_su_ClpX.
  IPR027417   P-loop_NTPase.
  IPR010603   Znf_CppX_C4.
  PF07724   AAA_2.
  PF10431   ClpB_D2-small.
  PF06689   zf-C4_ClpX.
  SM00382   AAA.
  SM01086   ClpB_D2-small.
  SM00994   zf-C4_ClpX.