UniProt Accession

 CLPP_ECO57;  P0A6G9;  P19245

Genbank Protein ID

 AE005174;  BA000007

Genbank Nucleotide ID

 AAG54787.1;  BAB33914.1

Protein Name

 ATP-dependent Clp protease proteolytic subunit

Protein Synonyms/Alias

 

Gene Name

 clpP

Gene Synonyms/Alias

 lopP; OrderedLocusNames=Z0542, ECs0491

Created Date

 3-June-2014

Organism

 Escherichia coli O157:H7

NCBI Taxa ID

 83334

Phosphorylation

Reference

 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; Cytoplasm; Hydrolase; Protease; Serineprotease; Zymogen

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0004252   F:serine-type endopeptidase activity IEA:UniProtKB-HAMAP

  IPR001907   ClpP.
  IPR023562   ClpP/TepA.
  IPR018215   ClpP_AS.

  PF00574   CLP_protease.

  PS00382   CLP_PROTEASE_HIS.
  PS00381   CLP_PROTEASE_SER.

  PR00127   CLPPROTEASEP.