※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exodeoxyribonuclease III
Protein Synonyms/Alias
 EXO III;  Exonuclease III
Gene Name
 xthA
Gene Synonyms/Alias
 xth; OrderedLocusNames=b1749, JW1738
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
109 NVTVINGYFPQGESR Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; DNAdamage; DNArepair; Exonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease; Referenceproteome
Protein Sequence
 MKFVSFNING LRARPHQLEA IVEKHQPDVI GLQETKVHDD MFPLEEVAKL GYNVFYHGQK 60
 GHYGVALLTK ETPIAVRRGF PGDDEEAQRR IIMAEIPSLL GNVTVINGYF PQGESRDHPI 120
 KFPAKAQFYQ NLQNYLETEL KRDNPVLIMG DMNISPTDLD IGIGEENRKR WLRTGKCSFL 180
 PEEREWMDRL MSWGLVDTFR HANPQTADRF SWFDYRSKGF DDNRGLRIDL LLASQPLAEC 240
 CVETGIDYEI RSMEKPSDHA PVWATFRR 268
  GO:0005622   C:intracellular IEA:InterPro
  GO:0003677   F:DNA binding IEA:InterPro
  GO:0004519   F:endonuclease activity IEA:InterPro
  GO:0008853   F:exodeoxyribonuclease III activity IDA:EcoCyc
  GO:0004527   F:exonuclease activity IDA:EcoCyc
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0006974   P:cellular response to DNA damage stimulus IDA:EcoCyc
  GO:0000738   P:DNA catabolic process, exonucleolytic IDA:GOC
  GO:0006281   P:DNA repair IEA:UniProtKB-KW
  GO:0090305   P:nucleic acid phosphodiester bond hydrolysis IDA:GOC
  IPR004808   AP_endonuc_1.
  IPR020847   AP_endonuclease_F1_BS.
  IPR020848   AP_endonuclease_F1_CS.
  IPR005135   Endo/exonuclease/phosphatase.
  PF03372   Exo_endo_phos.
  PS00726   AP_NUCLEASE_F1_1.
  PS00727   AP_NUCLEASE_F1_2.
  PS00728   AP_NUCLEASE_F1_3.
  PS51435   AP_NUCLEASE_F1_4.