※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoenolpyruvate-protein phosphotransferase
Protein Synonyms/Alias
 
Gene Name
 ptsI
Gene Synonyms/Alias
 b2416, JW2409
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
189 DAGGRTSHTSIMARS H LTP [1]
190 AGGRTSHTSIMARSL T HTP [2]
191 GGRTSHTSIMARSLE S HTP [2]
187 ITDAGGRTSHTSIMA T HTP [2]
188 TDAGGRTSHTSIMAR S HTP [2]
181 KKVLGFITDAGGRTS T HTP [2]
122 LEELDDEYLKERAAD Y HTP [3]
Reference
 [1]Reconstitution studies using the helical and carboxy-terminal domains of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system.
 Zhu PP,Szczepanowski RH,Nosworthy NJ,Ginsburg A,Peterkofsky A
 Biochemistry 1999, Nov, 23;38(47):15470-9. [PMID:10569929]
 [2]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
 [3]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; Kinase; Magnesium; Metal-binding; Phosphotransferasesystem; Referenceproteome; Sugartransport; Transferase; Transport
Protein Sequence
 MISGILASPG IAFGKALLLK EDEIVIDRKK ISADQVDQEV ERFLSGRAKA SAQLETIKTK 60
 AGETFGEEKE AIFEGHIMLL EDEELEQEII ALIKDKHMTA DAAAHEVIEG QASALEELDD 120
 EYLKERAADV RDIGKRLLRN ILGLKIIDLS AIQDEVILVA ADLTPSETAQ LNLKKVLGFI 180
 TDAGGRTSHT SIMARSLELP AIVGTGSVTS QVKNDDYLIL DAVNNQVYVN PTNEVIDKMR 240
 AVQEQVASEK AELAKLKDLP AITLDGHQVE VCANIGTVRD VEGAERNGAE GVGLYRTEFL 300
 FMDRDALPTE EEQFAAYKAV AEACGSQAVI VRTMDIGGDK ELPYMNFPKE ENPFLGWRAI 360
 RIAMDRREIL RDQLRAILRA SAFGKLRIMF PMIISVEEVR ALRKEIEIYK QELRDEGKAF 420
 DESIEIGVMV ETPAAATIAR HLAKEVDFFS IGTNDLTQYT LAVDRGNDMI SHLYQPMSPS 480
 VLNLIKQVID ASHAEGKWTG MCGELAGDER ATLLLLGMGL DEFSMSAISI PRIKKIIRNT 540
 NFEDAKVLAE QALAQPTTDE LMTLVNKFIE EKTIC 575
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0019197   C:phosphoenolpyruvate-dependent sugar phosphotransferase complex IDA:EcoCyc
  GO:0016301   F:kinase activity IEA:UniProtKB-KW
  GO:0000287   F:magnesium ion binding IDA:EcoCyc
  GO:0046872   F:metal ion binding IDA:EcoCyc
  GO:0008965   F:phosphoenolpyruvate-protein phosphotransferase activity IDA:EcoCyc
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IDA:EcoCyc
  IPR008279   PEP-util_enz_mobile_dom.
  IPR018274   PEP_util_AS.
  IPR000121   PEP_util_C.
  IPR023151   PEP_util_CS.
  IPR006318   PEP_util_enz.
  IPR024692   PTS_EI.
  IPR008731   PTS_EIN.
  IPR015813   Pyrv/PenolPyrv_Kinase-like_dom.
  PF05524   PEP-utilisers_N.
  PF00391   PEP-utilizers.
  PF02896   PEP-utilizers_C.
  PS00742   PEP_ENZYMES_2.
  PS00370   PEP_ENZYMES_PHOS_SITE.
  PR01736   PHPHTRNFRASE.