※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NADP]
Protein Synonyms/Alias
 IDH
Gene Name
 icd
Gene Synonyms/Alias
 icdA, icdE; OrderedLocusNames=b1136, JW1122
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
391 INAKTVTYDFERLMD Y HTP [1]
113 PVGGGIRSLNVALRQ S LTP;HTP [2,3],UniProt
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
 [2]Activation and expression of proteins during synchronous germination of aerial spores of Streptomyces granaticolor.
 Bobek J,Halada P,Angelis J,Vohradský J,Mikulík K
 Proteomics 2004, Dec;4(12):3864-80. [PMID:15378695]
 [3]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 
Sequence Annotation From UniProt
 MOD_RES 100 100 N6-succinyllysine
 MOD_RES 113 113 Phosphoserine
 MOD_RES 142 142 N6-acetyllysine
 MOD_RES 242 242 N6-succinyllysine
Key Word From UniProt
 3D-structure; Acetylation; Completeproteome; Directproteinsequencing; Glyoxylatebypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Referenceproteome; Tricarboxylicacidcycle
Protein Sequence
 MESKVVVPAQ GKKITLQNGK LNVPENPIIP YIEGDGIGVD VTPAMLKVVD AAVEKAYKGE 60
 RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK GPLTTPVGGG IRSLNVALRQ 120
 ELDLYICLRP VRYYQGTPSP VKHPELTDMV IFRENSEDIY AGIEWKADSA DAEKVIKFLR 180
 EEMGVKKIRF PEHCGIGIKP CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA 240
 FKDWGYQLAR EEFGGELIDG GPWLKVKNPN TGKEIVIKDV IADAFLQQIL LRPAEYDVIA 300
 CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK VNPGSIILSA 360
 EMMLRHMGWT EAADLIVKGM EGAINAKTVT YDFERLMDGA KLLKCSEFGD AIIENM 416
  GO:0005737   C:cytoplasm IDA:EcoliWiki
  GO:0004450   F:isocitrate dehydrogenase (NADP+) activity IDA:UniProtKB
  GO:0000287   F:magnesium ion binding IEA:InterPro
  GO:0051287   F:NAD binding IEA:InterPro
  GO:0022900   P:electron transport chain IMP:EcoliWiki
  GO:0006097   P:glyoxylate cycle IEA:UniProtKB-KW
  GO:0006099   P:tricarboxylic acid cycle IEA:UniProtKB-KW
  IPR019818   IsoCit/isopropylmalate_DH_CS.
  IPR001804   Isocitrate/isopropylmalate_DH.
  IPR004439   Isocitrate_DH_NADP_dimer_prok.
  IPR024084   IsoPropMal-DH-like_dom.
  PF00180   Iso_dh.
  PS00470   IDH_IMDH.