※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Protein Synonyms/Alias
 
Gene Name
 aceF
Gene Synonyms/Alias
 b0115, JW0111
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
115 VNVPDIGSDEVEVTE S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
Sequence Annotation From UniProt
 MOD_RES 41 41 N6-lipoyllysine
 MOD_RES 144 144 N6-lipoyllysine
 MOD_RES 245 245 N6-lipoyllysine
 MOD_RES 396 396 N6-acetyllysine
Key Word From UniProt
 3D-structure; Acetylation; Acyltransferase; Completeproteome; Directproteinsequencing; Glycolysis; Lipoyl; Referenceproteome; Repeat; Transferase
Protein Sequence
 MAIEIKVPDI GADEVEITEI LVKVGDKVEA EQSLITVEGD KASMEVPSPQ AGIVKEIKVS 60
 VGDKTQTGAL IMIFDSADGA ADAAPAQAEE KKEAAPAAAP AAAAAKDVNV PDIGSDEVEV 120
 TEILVKVGDK VEAEQSLITV EGDKASMEVP APFAGTVKEI KVNVGDKVST GSLIMVFEVA 180
 GEAGAAAPAA KQEAAPAAAP APAAGVKEVN VPDIGGDEVE VTEVMVKVGD KVAAEQSLIT 240
 VEGDKASMEV PAPFAGVVKE LKVNVGDKVK TGSLIMIFEV EGAAPAAAPA KQEAAAPAPA 300
 AKAEAPAAAP AAKAEGKSEF AENDAYVHAT PLIRRLAREF GVNLAKVKGT GRKGRILRED 360
 VQAYVKEAIK RAEAAPAATG GGIPGMLPWP KVDFSKFGEI EEVELGRIQK ISGANLSRNW 420
 VMIPHVTHFD KTDITELEAF RKQQNEEAAK RKLDVKITPV VFIMKAVAAA LEQMPRFNSS 480
 LSEDGQRLTL KKYINIGVAV DTPNGLVVPV FKDVNKKGII ELSRELMTIS KKARDGKLTA 540
 GEMQGGCFTI SSIGGLGTTH FAPIVNAPEV AILGVSKSAM EPVWNGKEFV PRLMLPISLS 600
 FDHRVIDGAD GARFITIINN TLSDIRRLVM 630
  GO:0005737   C:cytoplasm IDA:UniProtKB
  GO:0045254   C:pyruvate dehydrogenase complex IDA:EcoliWiki
  GO:0004742   F:dihydrolipoyllysine-residue acetyltransferase activity IDA:EcoliWiki
  GO:0031405   F:lipoic acid binding IDA:EcoliWiki
  GO:0006086   P:acetyl-CoA biosynthetic process from pyruvate IMP:EcoliWiki
  GO:0006096   P:glycolytic process IEA:UniProtKB-KW
  GO:0055114   P:oxidation-reduction process IDA:GOC
  GO:0006090   P:pyruvate metabolic process IMP:EcoliWiki
  IPR003016   2-oxoA_DH_lipoyl-BS.
  IPR001078   2-oxoacid_DH_actylTfrase.
  IPR006256   AcTrfase_Pyrv_DH_cplx.
  IPR000089   Biotin_lipoyl.
  IPR023213   CAT-like_dom.
  IPR004167   E3-bd.
  IPR011053   Single_hybrid_motif.
  PF00198   2-oxoacid_dh.
  PF00364   Biotin_lipoyl.
  PF02817   E3_binding.
  PS50968   BIOTINYL_LIPOYL.
  PS00189   LIPOYL.