UniProt Accession

 SP0A_BACSU;  P06534;  P70990

Genbank Protein ID

 M10082;  D84432;  AL009126;  U68235;  M23656

Genbank Nucleotide ID

 AAA22786.1;  BAA12581.1;  CAB14353.1;  AAC44872.1;  AAA22842.1

Protein Name

 Stage 0 sporulation protein A

Protein Synonyms/Alias

 

Gene Name

 spo0A

Gene Synonyms/Alias

 spo0C, spo0G; OrderedLocusNames=BSU24220

Created Date

 3-June-2014

Organism

 Bacillus subtilis (strain 168)

NCBI Taxa ID

 224308

Phosphorylation

Reference

 [1]Signal transduction and sporulation in Bacillus subtilis: heterologous phosphorylation of Spo0A, a sporulation initiation gene product.
 Asayama M,Kobayashi Y
 J. Biochem. 1993, Sep;114(3):385-8. [PMID:8282730]
 [2]Signal transduction and sporulation in Bacillus subtilis: autophosphorylation of Spo0A, a sporulation initiation gene product.
 Asayama M,Kobayashi Y
 Mol. Gen. Genet. 1993, Apr;238(1-2):138-44. [PMID:8479420]

Functional Description From UniProt

 FUNCTION: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box)

Sequence Annotation From UniProt

 MOD_RES 56 56 4-aspartylphosphate (By similarity)

Key Word From UniProt

 3D-structure; Activator; Calcium; Completeproteome; Cytoplasm; DNA-binding; Metal-binding; Phosphoprotein; Referenceproteome; Repressor; Sporulation; Transcription; Transcriptionregulation; Two-componentregulatorysystem

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005509   F:calcium ion binding IEA:InterPro
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0008356   P:asymmetric cell division IGI:UniProtKB
  GO:0000917   P:barrier septum assembly IGI:UniProtKB
  GO:0051606   P:detection of stimulus IEA:InterPro
  GO:0032022   P:multicellular pellicle formation IMP:CACAO
  GO:0045881   P:positive regulation of sporulation resulting in formation of a cellular spore IGI:UniProtKB
  GO:0030435   P:sporulation resulting in formation of a cellular spore IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW

  IPR011006   CheY-like_superfamily.
  IPR016032   Sig_transdc_resp-reg_C-effctor.
  IPR001789   Sig_transdc_resp-reg_receiver.
  IPR014879   Spo0A_C.
  IPR012052   Spore_0_A.
  IPR011991   WHTH_DNA-bd_dom.

  PF00072   Response_reg.
  PF08769   Spo0A_C.

  SM00448   REC.

  PS50110   RESPONSE_REGULATORY.