UniProt Accession

 PDXB_ECOLI;  P05459

Genbank Protein ID

 M29962;  U76961;  U00096;  AP009048;  X02743;  M15541

Genbank Nucleotide ID

 AAA24308.1;  AAB36530.1;  AAC75380.1;  BAA16177.1;  CAA26520.1;  AAA24310.1

Protein Name

 Erythronate-4-phosphate dehydrogenase

Protein Synonyms/Alias

 

Gene Name

 pdxB

Gene Synonyms/Alias

 b2320, JW2317

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [2]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]

Functional Description From UniProt

 FUNCTION: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; Cytoplasm; NAD; Oxidoreductase; Pyridoxinebiosynthesis; Referenceproteome

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0033711   F:4-phosphoerythronate dehydrogenase activity IDA:EcoCyc
  GO:0051287   F:NAD binding IDA:EcoCyc
  GO:0042823   P:pyridoxal phosphate biosynthetic process IDA:EcoCyc
  GO:0008615   P:pyridoxine biosynthetic process IDA:EcoCyc

  IPR006139   D-isomer_2_OHA_DH_cat_dom.
  IPR006140   D-isomer_2_OHA_DH_NAD-bd.
  IPR020921   Erythronate-4-P_DHase.
  IPR024531   Erythronate-4-P_DHase_dimer.
  IPR016040   NAD(P)-bd_dom.

  PF00389   2-Hacid_dh.
  PF02826   2-Hacid_dh_C.
  PF11890   DUF3410.

  PS00065   D_2_HYDROXYACID_DH_1.
  PS00671   D_2_HYDROXYACID_DH_3.