| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polyribonucleotide nucleotidyltransferase |
Protein Synonyms/Alias | PNPase |
Gene Name | pnp |
Gene Synonyms/Alias | b3164, JW5851 |
Created Date | 3-June-2014 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Phosphorylation | Position | Peptide | Code | Type | References | | 652 | KEGLVHISQIADKRV | S | HTP | [1] | |
Reference | [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M Mol. Cell Proteomics 2008, Feb;7(2):299-307. [ PMID:17938405] |
Functional Description From UniProt | FUNCTION: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Also involved, along with RNase II, in tRNA processing |
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| 3D-structure; Completeproteome; Cytoplasm; Directproteinsequencing; Magnesium; Metal-binding; Nucleotidyltransferase; Referenceproteome; RNA-binding; Stressresponse; Transferase |
Protein Sequence | MLNPIVRKFQ YGQHTVTLET GMMARQATAA VMVSMDDTAV FVTVVGQKKA KPGQDFFPLT 60
VNYQERTYAA GRIPGSFFRR EGRPSEGETL IARLIDRPIR PLFPEGFVNE VQVIATVVSV 120
NPQVNPDIVA MIGASAALSL SGIPFNGPIG AARVGYINDQ YVLNPTQDEL KESKLDLVVA 180
GTEAAVLMVE SEAQLLSEDQ MLGAVVFGHE QQQVVIQNIN ELVKEAGKPR WDWQPEPVNE 240
ALNARVAALA EARLSDAYRI TDKQERYAQV DVIKSETIAT LLAEDETLDE NELGEILHAI 300
EKNVVRSRVL AGEPRIDGRE KDMIRGLDVR TGVLPRTHGS ALFTRGETQA LVTATLGTAR 360
DAQVLDELMG ERTDTFLFHY NFPPYSVGET GMVGSPKRRE IGHGRLAKRG VLAVMPDMDK 420
FPYTVRVVSE ITESNGSSSM ASVCGASLAL MDAGVPIKAA VAGIAMGLVK EGDNYVVLSD 480
ILGDEDHLGD MDFKVAGSRD GISALQMDIK IEGITKEIMQ VALNQAKGAR LHILGVMEQA 540
INAPRGDISE FAPRIHTIKI NPDKIKDVIG KGGSVIRALT EETGTTIEIE DDGTVKIAAT 600
DGEKAKHAIR RIEEITAEIE VGRVYTGKVT RIVDFGAFVA IGGGKEGLVH ISQIADKRVE 660
KVTDYLQMGQ EVPVKVLEVD RQGRIRLSIK EATEQSQPAA APEAPAAEQG E 711 |
| GO:0005829 C:cytosol IDA:UniProtKB GO:0016020 C:membrane IDA:UniProtKB GO:0000175 F:3'-5'-exoribonuclease activity IDA:EcoCyc GO:0035438 F:cyclic-di-GMP binding IDA:EcoCyc GO:0042802 F:identical protein binding IPI:IntAct GO:0000287 F:magnesium ion binding IEA:UniProtKB-HAMAP GO:0004654 F:polyribonucleotide nucleotidyltransferase activity IDA:EcoCyc GO:0003723 F:RNA binding IEA:UniProtKB-HAMAP GO:0006402 P:mRNA catabolic process IEA:UniProtKB-HAMAP GO:0006950 P:response to stress IEA:UniProtKB-KW GO:0090503 P:RNA phosphodiester bond hydrolysis, exonucleolytic IDA:GOC GO:0006396 P:RNA processing IEA:InterPro |
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