※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator AppY
Protein Synonyms/Alias
 
Gene Name
 appY
Gene Synonyms/Alias
 b0564, JW0553
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
201 KLITSNSYSINVVAQ Y HTP [1]
202 LITSNSYSINVVAQK S HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; DNA-binding; Referenceproteome; Repressor; Transcription; Transcriptionregulation
Protein Sequence
 MDYVCSVVFI CQSFDLIINR RVISFKKNSL FIVSDKIRRE LPVCPSKLRI VDIDKKTCLS 60
 FFIDVNNELP GKFTLDKNGY IAEEEPPLSL VFSLFEGIKI ADSHSLWLKE RLCISLLAMF 120
 KKRESVNSFI LTNINTFTCK ITGIISFNIE RQWHLKDIAE LIYTSESLIK KRLRDEGTSF 180
 TEILRDTRMR YAKKLITSNS YSINVVAQKC GYNSTSYFIC AFKDYYGVTP SHYFEKIIGV 240
 TDGINKTID 249
  GO:0043565   F:sequence-specific DNA binding IEA:InterPro
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IDA:EcoCyc
  GO:0016036   P:cellular response to phosphate starvation IDA:EcoCyc
  GO:0045893   P:positive regulation of transcription, DNA-templated IDA:EcoCyc
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR009057   Homeodomain-like.
  IPR018060   HTH_AraC.
  IPR018062   HTH_AraC-typ_CS.
  IPR020449   Tscrpt_reg_HTH_AraC-type.
  PF12833   HTH_18.
  SM00342   HTH_ARAC.
  PS00041   HTH_ARAC_FAMILY_1.
  PS01124   HTH_ARAC_FAMILY_2.
  PR00032   HTHARAC.