UniProt Accession

 FMM1_NEIGO;  P02974

Genbank Protein ID

 K02078;  M13222

Genbank Nucleotide ID

 AAA25466.1;  AAA25468.1

Protein Name

 Fimbrial protein

Protein Synonyms/Alias

 

Gene Name

 pilE1

Gene Synonyms/Alias

 

Created Date

 3-June-2014

Organism

 Neisseria gonorrhoeae

NCBI Taxa ID

 485

Phosphorylation

Reference

 [1]Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili.
 Hegge FT,Hitchen PG,Aas FE,Kristiansen H,Løvold C,Egge-Jacobsen W,Panico M,Leong WY,Bull V,Virji M,Morris HR,Dell A,Koomey M
 Proc. Natl. Acad. Sci. U.S.A. 2004, Jul, 20;101(29):10798-803. [PMID:15249686]
 [2]Neisseria gonorrhoeae type IV pili undergo multisite, hierarchical modifications with phosphoethanolamine and phosphocholine requiring an enzyme structurally related to lipopolysaccharide phosphoethanolamine transferases.
 Aas FE,Egge-Jacobsen W,Winther-Larsen HC,Løvold C,Hitchen PG,Dell A,Koomey M
 J. Biol. Chem. 2006, Sep, 22;281(38):27712-23. [PMID:16825186]
 [3]Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology.
 Forest KT,Dunham SA,Koomey M,Tainer JA
 Mol. Microbiol. 1999, Feb;31(3):743-52. [PMID:10048019]

Functional Description From UniProt

 FUNCTION: This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells

Sequence Annotation From UniProt

 MOD_RES 8 8 N-methylphenylalanine
 MOD_RES 75 75 O-(2-aminoethylphosphoryl)serine alternate
 MOD_RES 75 75 O-(2-cholinephosphoryl)serine; alternate
 MOD_RES 75 75 Phosphoserine; alternate
 MOD_RES 101 101 O-(sn-1-glycerophosphoryl)serine partial
 DISULFID 128 158

Key Word From UniProt

 3D-structure; Celladhesion; Directproteinsequencing; Disulfidebond; Fimbrium; Glycoprotein; Methylation; Phosphoprotein

Protein Sequence

  GO:0009289   C:pilus IEA:UniProtKB-SubCell
  GO:0007155   P:cell adhesion IEA:UniProtKB-KW

  IPR012902   N_methyl_site.
  IPR001082   Pilin.

  PF13544   N_methyl_2.
  PF00114   Pilin.

  PS00409   PROKAR_NTER_METHYL.