※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methionine--tRNA ligase
Protein Synonyms/Alias
 MetRS
Gene Name
 metG
Gene Synonyms/Alias
 b2114, JW2101
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
665 GKDIFLLSPDAGAKP S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 FUNCTION: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Directproteinsequencing; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; Referenceproteome; RNA-binding; tRNA-binding; Zinc
Protein Sequence
 MTQVAKKILV TCALPYANGS IHLGHMLEHI QADVWVRYQR MRGHEVNFIC ADDAHGTPIM 60
 LKAQQLGITP EQMIGEMSQE HQTDFAGFNI SYDNYHSTHS EENRQLSELI YSRLKENGFI 120
 KNRTISQLYD PEKGMFLPDR FVKGTCPKCK SPDQYGDNCE VCGATYSPTE LIEPKSVVSG 180
 ATPVMRDSEH FFFDLPSFSE MLQAWTRSGA LQEQVANKMQ EWFESGLQQW DISRDAPYFG 240
 FEIPNAPGKY FYVWLDAPIG YMGSFKNLCD KRGDSVSFDE YWKKDSTAEL YHFIGKDIVY 300
 FHSLFWPAML EGSNFRKPSN LFVHGYVTVN GAKMSKSRGT FIKASTWLNH FDADSLRYYY 360
 TAKLSSRIDD IDLNLEDFVQ RVNADIVNKV VNLASRNAGF INKRFDGVLA SELADPQLYK 420
 TFTDAAEVIG EAWESREFGK AVREIMALAD LANRYVDEQA PWVVAKQEGR DADLQAICSM 480
 GINLFRVLMT YLKPVLPKLT ERAEAFLNTE LTWDGIQQPL LGHKVNPFKA LYNRIDMRQV 540
 EALVEASKEE VKAAAAPVTG PLADDPIQET ITFDDFAKVD LRVALIENAE FVEGSDKLLR 600
 LTLDLGGEKR NVFSGIRSAY PDPQALIGRH TIMVANLAPR KMRFGISEGM VMAAGPGGKD 660
 IFLLSPDAGA KPGHQVK 677
  GO:0005829   C:cytosol IDA:UniProtKB
  GO:0016020   C:membrane IDA:UniProtKB
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0004825   F:methionine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0000049   F:tRNA binding IEA:UniProtKB-HAMAP
  GO:0006431   P:methionyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR001412   aa-tRNA-synth_I_CS.
  IPR004495   Met-tRNA-synth_Ia_bsu_C.
  IPR023458   Met-tRNA_ligase_1.
  IPR014758   Met-tRNA_synth.
  IPR015413   Methionyl/Leucyl_tRNA_Synth.
  IPR012340   NA-bd_OB-fold.
  IPR014729   Rossmann-like_a/b/a_fold.
  IPR002547   tRNA-bd_dom.
  IPR009080   tRNAsynth_1a_anticodon-bd.
  PF09334   tRNA-synt_1g.
  PF01588   tRNA_bind.
  PS00178   AA_TRNA_LIGASE_I.
  PS50886   TRBD.
  PR01041   TRNASYNTHMET.