※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate cyclase
Protein Synonyms/Alias
 
Gene Name
 cyaA
Gene Synonyms/Alias
 cya; OrderedLocusNames=b3806, JW3778
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
407 FARRNNLSVSASPQD S HTP [1]
409 RRNNLSVSASPQDIG S HTP [1]
Reference
 [1]Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
 Macek B,Gnad F,Soufi B,Kumar C,Olsen JV,Mijakovic I,Mann M
 Mol. Cell Proteomics 2008, Feb;7(2):299-307. [PMID:17938405]
Functional Description From UniProt
 FUNCTION: Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp- cAMP, which then induces its own transcription again
Sequence Annotation From UniProt
 MOD_RES 609 609 Phosphohistidine; by CRR (Potential)
Key Word From UniProt
 ATP-binding; cAMPbiosynthesis; Completeproteome; Cytoplasm; Lyase; Nucleotide-binding; Phosphoprotein; Referenceproteome
Protein Sequence
 MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP GYLDGNVPKG 60
 ICLYTPDETQ RHYLNELELY RGMSVQDPPK GELPITGVYT MGSTSSVGQS CSSDLDIWVC 120
 HQSWLDSEER QLLQRKCSLL ENWAASLGVE VSFFLIDENR FRHNESGSLG GEDCGSTQHI 180
 LLLDEFYRTA VRLAGKRILW NMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA 240
 EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 300
 PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV LSQLVSEWGW 360
 DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 420
 KLYAAFEALP GKVTLVNPQI SPDLSEPNLT FIYVPPGRAN RSGWYLYNRA PNIESIISHQ 480
 PLEYNRYLNK LVAWAWFNGL LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP 540
 KALYSPCEIR HLAIIVNLEY DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN 600
 SWNEVRTLHF NGEQSMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI RTRVQQLVSE 660
 CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL ENAIEFYGAI SHNKLHGLSV 720
 QVETNHVKLP AVVDGFASEG IIQFFFEETQ DENGFNIYIL DESNRVEVYH HCEGSKEELV 780
 RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVKVDGREQV IPFRTKSIGN MPPANQDHDT 840
 PLLQQYFS 848
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004016   F:adenylate cyclase activity IDA:EcoCyc
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0006171   P:cAMP biosynthetic process IMP:EcoCyc
  IPR000274   Adenylate_cyclase_1.
  IPR024686   Adenylate_cyclase_1_CS.
  IPR024685   Adenylate_cyclase_1_N.
  PF12633   Adenyl_cycl_N.
  PF01295   Adenylate_cycl.
  PS01092   ADENYLATE_CYCLASE_1_1.
  PS01093   ADENYLATE_CYCLASE_1_2.