※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional aspartokinase/homoserine dehydrogenase 2
Protein Synonyms/Alias
 AKII-HDII
Gene Name
 metL
Gene Synonyms/Alias
 metM; OrderedLocusNames=b3940, JW3911
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
20 QLHKFGGSSLADVKC S HTP [1]
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
Functional Description From UniProt
 
Sequence Annotation From UniProt
 
Key Word From UniProt
 Amino-acidbiosynthesis; ATP-binding; Completeproteome; Directproteinsequencing; Kinase; Methioninebiosynthesis; Multifunctionalenzyme; NADP; Nucleotide-binding; Oxidoreductase; Referenceproteome; Transferase
Protein Sequence
 MSVIAQAGAK GRQLHKFGGS SLADVKCYLR VAGIMAEYSQ PDDMMVVSAA GSTTNQLINW 60
 LKLSQTDRLS AHQVQQTLRR YQCDLISGLL PAEEADSLIS AFVSDLERLA ALLDSGINDA 120
 VYAEVVGHGE VWSARLMSAV LNQQGLPAAW LDAREFLRAE RAAQPQVDEG LSYPLLQQLL 180
 VQHPGKRLVV TGFISRNNAG ETVLLGRNGS DYSATQIGAL AGVSRVTIWS DVAGVYSADP 240
 RKVKDACLLP LLRLDEASEL ARLAAPVLHA RTLQPVSGSE IDLQLRCSYT PDQGSTRIER 300
 VLASGTGARI VTSHDDVCLI EFQVPASQDF KLAHKEIDQI LKRAQVRPLA VGVHNDRQLL 360
 QFCYTSEVAD SALKILDEAG LPGELRLRQG LALVAMVGAG VTRNPLHCHR FWQQLKGQPV 420
 EFTWQSDDGI SLVAVLRTGP TESLIQGLHQ SVFRAEKRIG LVLFGKGNIG SRWLELFARE 480
 QSTLSARTGF EFVLAGVVDS RRSLLSYDGL DASRALAFFN DEAVEQDEES LFLWMRAHPY 540
 DDLVVLDVTA SQQLADQYLD FASHGFHVIS ANKLAGASDS NKYRQIHDAF EKTGRHWLYN 600
 ATVGAGLPIN HTVRDLIDSG DTILSISGIF SGTLSWLFLQ FDGSVPFTEL VDQAWQQGLT 660
 EPDPRDDLSG KDVMRKLVIL AREAGYNIEP DQVRVESLVP AHCEGGSIDH FFENGDELNE 720
 QMVQRLEAAR EMGLVLRYVA RFDANGKARV GVEAVREDHP LASLLPCDNV FAIESRWYRD 780
 NPLVIRGPGA GRDVTAGAIQ SDINRLAQLL 810
  GO:0004072   F:aspartate kinase activity IDA:EcoCyc
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0004412   F:homoserine dehydrogenase activity IDA:EcoCyc
  GO:0050661   F:NADP binding IEA:InterPro
  GO:0009090   P:homoserine biosynthetic process IDA:EcoCyc
  GO:0009089   P:lysine biosynthetic process via diaminopimelate IDA:EcoCyc
  GO:0009086   P:methionine biosynthetic process IEA:UniProtKB-KW
  GO:0009088   P:threonine biosynthetic process IEA:UniProtKB-UniPathway
  IPR001048   Asp/Glu/Uridylate_kinase.
  IPR005106   Asp/hSer_DH_NAD-bd.
  IPR001341   Asp_kinase_dom.
  IPR018042   Aspartate_kinase_CS.
  IPR011147   Bifunc_aspartokin/hSer_DH.
  IPR001342   HDH_cat.
  IPR019811   HDH_CS.
  IPR016040   NAD(P)-bd_dom.
  PF00696   AA_kinase.
  PF00742   Homoserine_dh.
  PF03447   NAD_binding_3.
  PS00324   ASPARTOKINASE.
  PS01042   HOMOSER_DHGENASE.