※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PTS system mannitol-specific EIICBA component
Protein Synonyms/Alias
 EII-Mtl
Gene Name
 mtlA
Gene Synonyms/Alias
 b3599, JW3573
Created Date
 3-June-2014
Organism
 Escherichia coli (strain K12)
NCBI Taxa ID
 83333
Phosphorylation
Position
Peptide
Code
Type
References
490 KDSFDDSSANLFKLG S HTP [1]
554 GESIAVPHGTVEAKD H LTP [2,3],UniProt
Reference
 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]
 [2]A proposed link between nitrogen and carbon metabolism involving protein phosphorylation in bacteria.
 Reizer J,Reizer A,Saier MH,Jacobson GR
 Protein Sci. 1992, Jun;1(6):722-6. [PMID:1304914]
 [3]Three-dimensional solution structure of the cytoplasmic B domain of the mannitol transporter IImannitol of the Escherichia coli phosphotransferase system.
 Legler PM,Cai M,Peterkofsky A,Clore GM
 J. Biol. Chem. 2004, Sep, 10;279(37):39115-21. [PMID:15258141]
Functional Description From UniProt
 FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport
Sequence Annotation From UniProt
 TRANSMEM 25 44 Helical; (Probable)
 TRANSMEM 51 69 Helical; (Probable)
 TRANSMEM 135 154 Helical; (Probable)
 TRANSMEM 166 184 Helical; (Probable)
 TRANSMEM 274 291 Helical; (Probable)
 TRANSMEM 314 333 Helical; (Probable)
 MOD_RES 384 384 Phosphocysteine
 MOD_RES 554 554 Phosphohistidine
Key Word From UniProt
 3D-structure; Cellinnermembrane; Cellmembrane; Completeproteome; Kinase; Membrane; Phosphoprotein; Phosphotransferasesystem; Referenceproteome; Sugartransport; Transferase; Transmembrane; Transmembranehelix; Transport
Protein Sequence
 MSSDIKIKVQ SFGRFLSNMV MPNIGAFIAW GIITALFIPT GWLPNETLAK LVGPMITYLL 60
 PLLIGYTGGK LVGGERGGVV GAITTMGVIV GADMPMFLGS MIAGPLGGWC IKHFDRWVDG 120
 KIKSGFEMLV NNFSAGIIGM ILAILAFLGI GPIVEALSKM LAAGVNFMVV HDMLPLASIF 180
 VEPAKILFLN NAINHGIFSP LGIQQSHELG KSIFFLIEAN PGPGMGVLLA YMFFGRGSAK 240
 QSAGGAAIIH FLGGIHEIYF PYVLMNPRLI LAVILGGMTG VFTLTILGGG LVSPASPGSI 300
 LAVLAMTPKG AYFANIAGVC AAMAVSFVVS AILLKTSKVK EEDDIEAATR RMQDMKAESK 360
 GASPLSAGDV TNDLSHVRKI IVACDAGMGS SAMGAGVLRK KIQDAGLSQI SVTNSAINNL 420
 PPDVDLVITH RDLTERAMRQ VPQAQHISLT NFLDSGLYTS LTERLVAAQR HTANEEKVKD 480
 SLKDSFDDSS ANLFKLGAEN IFLGRKAATK EEAIRFAGEQ LVKGGYVEPE YVQAMLDREK 540
 LTPTYLGESI AVPHGTVEAK DRVLKTGVVF CQYPEGVRFG EEEDDIARLV IGIAARNNEH 600
 IQVITSLTNA LDDESVIERL AHTTSVDEVL ELLAGRK 637
  GO:0016021   C:integral component of membrane IEA:UniProtKB-KW
  GO:0005886   C:plasma membrane IEA:UniProtKB-SubCell
  GO:0016301   F:kinase activity IEA:UniProtKB-KW
  GO:0008982   F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IEA:UniProtKB-EC
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IEA:UniProtKB-KW
  IPR016152   PTrfase/Anion_transptr.
  IPR002178   PTS_EIIA_type-2_dom.
  IPR013011   PTS_EIIB_2.
  IPR003501   PTS_EIIB_2/3.
  IPR003352   PTS_EIIC.
  IPR013014   PTS_EIIC_2.
  IPR004718   PTS_IIC_mtl.
  PF00359   PTS_EIIA_2.
  PF02378   PTS_EIIC.
  PF02302   PTS_IIB.
  PS51094   PTS_EIIA_TYPE_2.
  PS00372   PTS_EIIA_TYPE_2_HIS.
  PS51099   PTS_EIIB_TYPE_2.
  PS51104   PTS_EIIC_TYPE_2.