※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation initiation factor 2 subunit alpha
Protein Synonyms/Alias
 
Gene Name
 eif2a
Gene Synonyms/Alias
 PH0961
Created Date
 3-June-2014
Organism
 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
NCBI Taxa ID
 70601
Phosphorylation
Position
Peptide
Code
Type
References
48 MHISEVASTWVRNIR S LTP;HTP [1,2]
Reference
 [1]In vitro phosphorylation of initiation factor 2 alpha (aIF2 alpha) from hyperthermophilic archaeon Pyrococcus horikoshii OT3.
 Tahara M,Ohsawa A,Saito S,Kimura M
 J. Biochem. 2004, Apr;135(4):479-85. [PMID:15115772]
 [2]Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life.
 Aivaliotis M,Macek B,Gnad F,Reichelt P,Mann M,Oesterhelt D
 PLoS ONE 2009;4(3):e4777. [PMID:19274099]
Functional Description From UniProt
 FUNCTION: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 3D-structure; Completeproteome; Initiationfactor; Proteinbiosynthesis; RNA-binding
Protein Sequence
 MPRKAREYPE EGEFVVATVK RIHNYGAFLE LDEYPGKEAF MHISEVASTW VRNIRDYLKE 60
 GQKVVAKVIR VDPRKGHIDL SLRRVTQQQR KAKLQEFKRA QKAENLLRLA AEKLGKDFEA 120
 AWREVWVPLE EEWGEVYAAF EDAAKDGIEV LKGHVPDEWL PVLKEIVENY VEVPTVTIDA 180
 EFEITVPKPN GVEIIKEALI RARDRANKEK DIEVKFTYQG APRYRIDITA PDYYKAEEVL 240
 EDIAEEILRV IKQAGGEATL LRKEKRIRKV KKRKK 275
  GO:0005850   C:eukaryotic translation initiation factor 2 complex IEA:InterPro
  GO:0003743   F:translation initiation factor activity IEA:UniProtKB-HAMAP
  IPR012340   NA-bd_OB-fold.
  IPR003029   Rbsml_prot_S1_RNA-bd_dom.
  IPR022967   RNA-binding_domain_S1.
  IPR022964   TIF2_asu_arc.
  IPR024055   TIF2_asu_C.
  IPR024054   TIF2_asu_middle.
  IPR011488   TIF_2_asu.
  PF07541   EIF_2_alpha.
  PF00575   S1.
  SM00316   S1.
  PS50126   S1.