UniProt Accession

 PYRE_SULAC;  O08359;  Q4J8H0

Genbank Protein ID

 Y12822;  AJ459777;  CP000077

Genbank Nucleotide ID

 CAA73352.1;  CAD31975.1;  AAY80910.1

Protein Name

 Orotate phosphoribosyltransferase

Protein Synonyms/Alias

 OPRT;  OPRTase

Gene Name

 pyrE

Gene Synonyms/Alias

 Saci_1597

Created Date

 3-June-2014

Organism

 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)

NCBI Taxa ID

 330779

Phosphorylation

Reference

 [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius.
 Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV
 Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [PMID:24078887]

Functional Description From UniProt

 FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; Glycosyltransferase; Magnesium; Pyrimidinebiosynthesis; Transferase

Protein Sequence

  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0004588   F:orotate phosphoribosyltransferase activity IEA:UniProtKB-HAMAP
  GO:0044205   P:'de novo' UMP biosynthetic process IEA:UniProtKB-UniPathway

  IPR023031   OPRT.
  IPR004467   Or_phspho_trans_dom.
  IPR000836   PRibTrfase_dom.

  PF00156   Pribosyltran.