Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteasome-activating nucleotidase |
Protein Synonyms/Alias | PAN |
Gene Name | pan |
Gene Synonyms/Alias | C498_14488 |
Created Date | 3-June-2014 |
Organism | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) |
NCBI Taxa ID | 309800 |
Phosphorylation | Position | Peptide | Code | Type | References | 369 | HTRKMNVSDDVDFVE | S | HTP | [1] | |
Reference | [1]Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii. Humbard MA,Reuter CJ,Zuobi-Hasona K,Zhou G,Maupin-Furlow JA Archaea 2010;:481725. [ PMID:20671954] |
Functional Description From UniProt | FUNCTION: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates (By similarity) |
| COILED 12 71 By similarity |
| ATP-binding; Chaperone; Coiledcoil; Cytoplasm; Nucleotide-binding; Proteasome |
Protein Sequence | MTDTVDDVDL PYDKDSASQQ EKITALQERL EVLETQNEEM RDKLLDTNAE NNKYQQKLER 60 LTHENKKLKQ SPLFVATVQE ITDEGVIIKQ HGNNQEALTE VTDEMREELE PDARVAVNNS 120 LSIVKRLDKE TDVRARVMQV EHSPDVTYED IGGLEEQMQE VRETVEMPLD RPEMFAEVGI 180 DPPSGVLLYG PPGTGKTMLA XPEMFAEVGI DPPSGVLLYG PPGTGKTMLA KAVANQTNAS 240 FIKMAGSELV HKFIGEGAKL VRDLFEVARE NEPAVIFIDE IDAIASKRTD SKTSGDAEVQ 300 RTMMQLLAEM DGFDERGNIR IIAATNRFDM LDPAILRPGR FDRLIEVPKP NEDGREIIFQ 360 IHTRKMNVSD DVDFVELAEM ADNASGADIK AVCTEAGMFA IRDDRTEIFM QDFVDAWEKI 420 QQEASDETEV SRAFA 435 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0022623 C:proteasome-activating nucleotidase complex IEA:UniProtKB-HAMAP GO:0005524 F:ATP binding IEA:UniProtKB-HAMAP GO:0016887 F:ATPase activity IEA:UniProtKB-HAMAP GO:0010498 P:proteasomal protein catabolic process IEA:UniProtKB-HAMAP GO:0043335 P:protein unfolding IEA:UniProtKB-HAMAP |
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