※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proteasome-activating nucleotidase
Protein Synonyms/Alias
 PAN
Gene Name
 pan
Gene Synonyms/Alias
 C498_14488
Created Date
 3-June-2014
Organism
 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
NCBI Taxa ID
 309800
Phosphorylation
Position
Peptide
Code
Type
References
369 HTRKMNVSDDVDFVE S HTP [1]
Reference
 [1]Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii.
 Humbard MA,Reuter CJ,Zuobi-Hasona K,Zhou G,Maupin-Furlow JA
 Archaea 2010;:481725. [PMID:20671954]
Functional Description From UniProt
 FUNCTION: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates (By similarity)
Sequence Annotation From UniProt
 COILED 12 71 By similarity
Key Word From UniProt
 ATP-binding; Chaperone; Coiledcoil; Cytoplasm; Nucleotide-binding; Proteasome
Protein Sequence
 MTDTVDDVDL PYDKDSASQQ EKITALQERL EVLETQNEEM RDKLLDTNAE NNKYQQKLER 60
 LTHENKKLKQ SPLFVATVQE ITDEGVIIKQ HGNNQEALTE VTDEMREELE PDARVAVNNS 120
 LSIVKRLDKE TDVRARVMQV EHSPDVTYED IGGLEEQMQE VRETVEMPLD RPEMFAEVGI 180
 DPPSGVLLYG PPGTGKTMLA XPEMFAEVGI DPPSGVLLYG PPGTGKTMLA KAVANQTNAS 240
 FIKMAGSELV HKFIGEGAKL VRDLFEVARE NEPAVIFIDE IDAIASKRTD SKTSGDAEVQ 300
 RTMMQLLAEM DGFDERGNIR IIAATNRFDM LDPAILRPGR FDRLIEVPKP NEDGREIIFQ 360
 IHTRKMNVSD DVDFVELAEM ADNASGADIK AVCTEAGMFA IRDDRTEIFM QDFVDAWEKI 420
 QQEASDETEV SRAFA 435
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0022623   C:proteasome-activating nucleotidase complex IEA:UniProtKB-HAMAP
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0016887   F:ATPase activity IEA:UniProtKB-HAMAP
  GO:0010498   P:proteasomal protein catabolic process IEA:UniProtKB-HAMAP
  GO:0043335   P:protein unfolding IEA:UniProtKB-HAMAP
  IPR005937   26S_Psome_P45.
  IPR003593   AAA+_ATPase.
  IPR003959   ATPase_AAA_core.
  IPR003960   ATPase_AAA_CS.
  IPR023501   Nucleotidase_PAN.
  IPR027417   P-loop_NTPase.
  PF00004   AAA.
  SM00382   AAA.
  PS00674   AAA.