UniProt Accession

 GRPE_LISM4;  G2K047;  Q76N48;  Q9S5A5

Genbank Protein ID

 AB023064;  AB007771;  CP002002

Genbank Nucleotide ID

 BAA82788.1;  BAD07396.1;  AEO06459.1

Protein Name

 Protein GrpE

Protein Synonyms/Alias

 

Gene Name

 grpE

Gene Synonyms/Alias

 LMRG_00927

Created Date

 3-June-2014

Organism

 Listeria monocytogenes serotype 1/2a (strain 10403S)

NCBI Taxa ID

 393133

Phosphorylation

Reference

 [1]Analysis of the serine/threonine/tyrosine phosphoproteome of the pathogenic bacterium Listeria monocytogenes reveals phosphorylated proteins related to virulence.
 Misra SK,Milohanic E,Aké F,Mijakovic I,Deutscher J,Monnet V,Henry C
 Proteomics 2011, Nov;11(21):4155-65. [PMID:21956863]

Functional Description From UniProt

 FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Chaperone; Completeproteome; Cytoplasm; Stressresponse.

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0000774   F:adenyl-nucleotide exchange factor activity IEA:InterPro
  GO:0006457   P:protein folding IEA:InterPro
  GO:0006950   P:response to stress IEA:UniProtKB-KW

  IPR000740   GrpE.
  IPR013805   GrpE_coiled_coil.
  IPR009012   GrpE_head.

  PF01025   GrpE.

  PS01071   GRPE.

  PR00773   GRPEPROTEIN.