| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteasome-activating nucleotidase 1 |
Protein Synonyms/Alias | PAN 1 |
Gene Name | pan1 |
Gene Synonyms/Alias | panA; OrderedLocusNames=HVO_0850 |
Created Date | 3-June-2014 |
Organism | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) |
NCBI Taxa ID | 309800 |
Phosphorylation | Position | Peptide | Code | Type | References | | 340 | HTRKMNVSDDVDFVE | S | HTP | [1] | |
Reference | [1]Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii. Humbard MA,Reuter CJ,Zuobi-Hasona K,Zhou G,Maupin-Furlow JA Archaea 2010;:481725. [ PMID:20671954] |
Functional Description From UniProt | FUNCTION: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-terminus of the proteasomal ATPase functions like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates (Probable). Is also able to cleave other nucleoside triphosphates including GTP and TTP, but the rate of hydrolysis is 4- to 5-fold slower than for ATP |
| COILED 13 72 Potential |
| ATP-binding; Chaperone; Coiledcoil; Completeproteome; Cytoplasm; Nucleotide-binding; Proteasome; Referenceproteome |
Protein Sequence | MMTDTVDDVD LPYDKDSASQ QEKITALQER LEVLETQNEE MRDKLLDTNA ENNKYQQKLE 60
RLTHENKKLK QSPLFVATVQ EITDEGVIIK QHGNNQEALT EVTDEMREEL EPDARVAVNN 120
SLSIVKRLDK ETDVRARVMQ VEHSPDVTYE DIGGLEEQMQ EVRETVEMPL DRPEMFAEVG 180
IDPPSGVLLY GPPGTGKTML AKAVANQTNA SFIKMAGSEL VHKFIGEGAK LVRDLFEVAR 240
ENEPAVIFID EIDAIASKRT DSKTSGDAEV QRTMMQLLAE MDGFDERGNI RIIAATNRFD 300
MLDPAILRPG RFDRLIEVPK PNEDGREIIF QIHTRKMNVS DDVDFVELAE MADNASGADI 360
KAVCTEAGMF AIRDDRTEIF MQDFVDAWEK IQQEASDETE VSRAFA 406 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0022623 C:proteasome-activating nucleotidase complex IEA:UniProtKB-HAMAP GO:0005524 F:ATP binding IEA:UniProtKB-HAMAP GO:0016887 F:ATPase activity IEA:UniProtKB-HAMAP GO:0010498 P:proteasomal protein catabolic process IEA:UniProtKB-HAMAP GO:0043335 P:protein unfolding IEA:UniProtKB-HAMAP |
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