※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chaperone protein DnaJ
Protein Synonyms/Alias
 
Gene Name
 dnaJ
Gene Synonyms/Alias
 SYNPCC7002_A0693
Created Date
 3-June-2014
Organism
 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
NCBI Taxa ID
 32049
Phosphorylation
Position
Peptide
Code
Type
References
231 TIPAGVDSGTRLRVS S HTP [1]
Reference
 [1]Global phosphoproteomic analysis reveals diverse functions of serine/threonine/tyrosine phosphorylation in the model cyanobacterium Synechococcus sp. strain PCC 7002.
 Yang MK,Qiao ZX,Zhang WY,Xiong Q,Zhang J,Li T,Ge F,Zhao JD
 J. Proteome Res. 2013, Apr, 5;12(4):1909-23. [PMID:23461524]
Functional Description From UniProt
 FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Chaperone; Completeproteome; Cytoplasm; DNAreplication; Metal-binding; Repeat; Stressresponse; Zinc; Zinc-finger
Protein Sequence
 MAGDFYEILG VSRDCGKDEL KRAYRRLARQ YHPDVNKDPG AEEKFKEINR AYEVLSEPET 60
 RARYDRFGEA GVSGAGAAGA DYGDMGGFAD IFETIFSGFG GMGTGATGGG RRRSGPMRGD 120
 DLRLDLKLDF KEAIFGGEKE IRIPHLETCK TCSGSGAKAG TSANTCGTCN GTGQVRRATR 180
 TPFGSFAQVS VCPTCNGEGQ VIAEKCESCG GAGRKQETKK LKITIPAGVD SGTRLRVSRE 240
 GDAGVKGGPP GDLYVYLAVN ADKEFRRDGT NILSEIEISY LQAILGDTVK VKTVDGTEDL 300
 TIPAGLQPNK VLILEGKGVP KLGNPVSRGD HLITVKVMIP TKVSREEKEL LHQLAKLKGT 360
 EHSKGGFEGL LGNLFHNK 378
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:InterPro
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006260   P:DNA replication IEA:UniProtKB-KW
  GO:0006457   P:protein folding IEA:InterPro
  GO:0009408   P:response to heat IEA:InterPro
  IPR012724   DnaJ.
  IPR002939   DnaJ_C.
  IPR001623   DnaJ_domain.
  IPR008971   HSP40/DnaJ_pept-bd.
  IPR001305   HSP_DnaJ_Cys-rich_dom.
  PF01556   CTDII.
  PF00226   DnaJ.
  PF00684   DnaJ_CXXCXGXG.
  SM00271   DnaJ.
  PS50076   DNAJ_2.
  PS51188   ZF_CR.
  PR00625   JDOMAIN.