| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription-repair-coupling factor |
Protein Synonyms/Alias | TRCF |
Gene Name | mfd |
Gene Synonyms/Alias | SYNPCC7002_A1287 |
Created Date | 3-June-2014 |
Organism | Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) |
NCBI Taxa ID | 32049 |
Phosphorylation | Position | Peptide | Code | Type | References | | 1124 | HLQSRFVYTSKKVTV | Y | HTP | [1] | | 1125 | LQSRFVYTSKKVTVR | T | HTP | [1] | | 1130 | VYTSKKVTVRGLGAM | T | HTP | [1] | |
Reference | [1]Global phosphoproteomic analysis reveals diverse functions of serine/threonine/tyrosine phosphorylation in the model cyanobacterium Synechococcus sp. strain PCC 7002. Yang MK,Qiao ZX,Zhang WY,Xiong Q,Zhang J,Li T,Ge F,Zhao JD J. Proteome Res. 2013, Apr, 5;12(4):1909-23. [ PMID:23461524] |
Functional Description From UniProt | FUNCTION: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity) |
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| ATP-binding; Completeproteome; Cytoplasm; DNAdamage; DNArepair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding |
Protein Sequence | MTFSSVVRFL SRAALTAELN QKLQTQGELA LSGLPRLPKG LLASSLAQLQ EKNLLVVCAT 60
LEEAGRWAAQ LEAMGWGQVL FYPTSEASPY EAFDPESEMI WGQMQTLGAI AQGQSSNVGK 120
GMVVVTTERA LQPHLPPQTV FQDYCLTLTP GEELDHAGAI ATQLTRLGYE RVNIVETEGQ 180
WTRRGDIVDI FPVSGELPIR LDFFGDQLES IREFDPNSQR SLDKVDQLVL TPTAWAPLIG 240
QQILDPADLP LTPEEKEQWA DGVYPEGMQR FLGIAFADQV ASILEYLPEN TLVAIDELSQ 300
CLAHGDRTYE TSEAQWQLLN GDFPLPKIHR RVQENFDQVS QRYQKITLAE LDDVSETSVN 360
LSSRPVPITP HQFGKLAEIL RGKREIYSTI TLDKYNAWLV SAQPSRSVSL LQEHDCAAQF 420
IPNPRDYPAI EKHQRQGTAI ALKYKGQAEL EGFILPTFRI AVVTDREFYG QHALTTFGYI 480
RKRRRAASKT VDVNKLNPGD YIVHKSHGIG RFIKIETLQS REYLVLKYAD GILRIPADSL 540
DTLSRYRHTA KGRPELHRMG GKTWEKTKAK VRKSVKKLAV DLLKIYAQRA EMKGITYPSD 600
APWQQEMEDS FPYQATPDQL KAVQDIKRDL ESDRPMDRLV CGDVGFGKTE VAIRAIFKVV 660
TGGHKQVALL APTTILTQQH YHTLKERFSP YPINIGLLNR FRTASERKDI LERLHKGELD 720
IVVGTQQLLG KDVQFKDLGL LVVDEEQRFG VNQKEKIKAL KTKVDVLTLS ATPIPRTLYM 780
SLSGIREMSL ITTPPPSRRP IQTHVSRHNP EIIRTAIRNE LDRGGQIFYV VPRVEGIETI 840
ATQLQEMIPS ARVAIAHGQM NEADLETTML TFNNGEADIL LCTTIVESGL DIPRVNTIIV 900
EDAQKFGLSQ LYQLRGRVGR SGIQAHAWLL YPSKGELTEK ARKRLRALQE FSQLGSGYQL 960
AMRDMEIRGV GNLLGAEQSG QMEAIGFDLY MEMLQDCISE IRGQEIPQVD DCQVDLRLTA 1020
FIPSNYITDG DQKLDAYRLI TQANSKLELM QIAADWGDRY GKLPPSVEQL LQVIELKMIA 1080
KSLGFARIKP EGKQNIVLET PMEEPAWQRF AEKLPSHLQS RFVYTSKKVT VRGLGAMKPQ 1140
QQLDSLIEWL GRMQGVLEEA RV 1162 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0005524 F:ATP binding IEA:UniProtKB-HAMAP GO:0008026 F:ATP-dependent helicase activity IEA:InterPro GO:0003684 F:damaged DNA binding IEA:InterPro GO:0006355 P:regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP GO:0000716 P:transcription-coupled nucleotide-excision repair, DNA damage recognition IEA:UniProtKB-HAMAP |
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