※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inosine-5'-monophosphate dehydrogenase
Protein Synonyms/Alias
 IMP dehydrogenase;  IMPD;  IMPDH
Gene Name
 guaB
Gene Synonyms/Alias
 OE_2458R
Created Date
 3-June-2014
Organism
 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
NCBI Taxa ID
 478009
Phosphorylation
Position
Peptide
Code
Type
References
5 ***MANDSSTDGRFS S HTP [1]
6 **MANDSSTDGRFSE S HTP [1]
7 *MANDSSTDGRFSEK T HTP [1]
Reference
 [1]Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life.
 Aivaliotis M,Macek B,Gnad F,Reichelt P,Mann M,Oesterhelt D
 PLoS ONE 2009;4(3):e4777. [PMID:19274099]
Functional Description From UniProt
 FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 CBSdomain; Completeproteome; GMPbiosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purinebiosynthesis; Repeat
Protein Sequence
 MANDSSTDGR FSEKLRVPEA LTFDDVLLRP AESRVEPDDA DVATRVSTNV ELEVPVLSAA 60
 MDTVTESRLA IAMAREGGLG VLHQNMDTDR VVAEVERVKR ADELVIDREN VVTAAPEQTV 120
 EAVDEMMDRS DVSGAPVVDD DDTVRGIISA TDIRPYLEVG ESDAVREAMT DEVITAPEDI 180
 TARDALELMY EHKIERVPIV NDEQHLVGLV TMQGILERRE HGSAARDQNG RLRVGVAVGP 240
 FDTERATAVD EAGADVLFID CAHAHNLNVI DSAREIKASV DADVVVGNVG TREAAEAVVD 300
 FADGIKVGIG PGSICTTRVV TGSGMPQITA VSQVADVAAP AGVPVIADGG IRYSGDAAKA 360
 IAAGADAVML GSYFAGTDEA PGRVITMNGK KYKQYRGMGS VGAMQSGGSD RYLKDDDEDE 420
 EYVPEGVEAA TPYKGSLASE LHQLVGGIQS GMGYVGAESI PAFKADAEFV RVSAAGQTEG 480
 HPHDVMITDE APNYSPQGE 499
  GO:0030554   F:adenyl nucleotide binding IEA:InterPro
  GO:0003938   F:IMP dehydrogenase activity IEA:UniProtKB-HAMAP
  GO:0046872   F:metal ion binding IEA:UniProtKB-HAMAP
  GO:0006177   P:GMP biosynthetic process IEA:UniProtKB-HAMAP
  IPR013785   Aldolase_TIM.
  IPR000644   CBS_dom.
  IPR005990   IMP_DH.
  IPR015875   IMP_DH/GMP_Rdtase_CS.
  IPR001093   IMP_DH_GMPRt.
  PF00571   CBS.
  PF00478   IMPDH.
  SM00116   CBS.
  PS51371   CBS.
  PS00487   IMP_DH_GMP_RED.