Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein GrpE |
Protein Synonyms/Alias | |
Gene Name | grpE |
Gene Synonyms/Alias | OE_1742R |
Created Date | 3-June-2014 |
Organism | Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) |
NCBI Taxa ID | 478009 |
Phosphorylation | Position | Peptide | Code | Type | References | 2 | ******MSDHAEHAA | S | HTP | [1] | |
Reference | [1]Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life. Aivaliotis M,Macek B,Gnad F,Reichelt P,Mann M,Oesterhelt D PLoS ONE 2009;4(3):e4777. [ PMID:19274099] |
Functional Description From UniProt | FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity) |
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| Chaperone; Completeproteome; Cytoplasm; Stressresponse. |
Protein Sequence | MSDHAEHAAD AADTDAPEGD DAGGDDGEQA GDDGTSALSE RVRALDADNA DALADDVAAL 60 EARVETLTDE LADAEDEVAD LTERVQTKQA DFKNYKERAK RKQEEIRERA TEDLVERLLD 120 VRDNLDRALD QEESESDEDG IREGVELTRD EFDRVLETEG VTEIRPEPGD SVDAARHEVM 180 MRVDSDQPAG TIVDVYRPGY EMSGRVVRAA QVTVSEE 217 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0000774 F:adenyl-nucleotide exchange factor activity IEA:InterPro GO:0006457 P:protein folding IEA:InterPro GO:0006950 P:response to stress IEA:UniProtKB-KW |
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