Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Luminescence regulatory protein LuxO |
Protein Synonyms/Alias | |
Gene Name | luxO |
Gene Synonyms/Alias | VIBHAR_02959 |
Created Date | 3-June-2014 |
Organism | Vibrio campbellii (strain ATCC BAA-1116 / BB120) |
NCBI Taxa ID | 338187 |
Phosphorylation | Position | Peptide | Code | Type | References | 47 | IPDLILLDLRLPDMT | D | LTP | [1] | |
Reference | [1]A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi. Freeman JA,Bassler BL Mol. Microbiol. 1999, Jan;31(2):665-77. [ PMID:10027982] |
Functional Description From UniProt | FUNCTION: Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype |
| MOD_RES 47 47 4-aspartylphosphate (Probable) |
| ATP-binding; Completeproteome; DNA-binding; Nucleotide-binding; Phosphoprotein; Repressor; Transcription; Transcriptionregulation; Two-componentregulatorysystem |
Protein Sequence | MVEDTASVAA LYRSYLTPLG IDINIVGTGR DAIESLNHRI PDLILLDLRL PDMTGMDVLH 60 AVKKSHPDVP IIFMTAHGSI DTAVEAMRHG SQDFLIKPCE ADRLRVTVNN AIRKATKLKN 120 EADNPGNQNY QGFIGSSQTM QQVYRTIDSA ASSKASIFIT GESGTGKEVC AEAIHAASKR 180 GDKPFIAINC AAIPKDLIES ELFGHVKGAF TGAANDRQGA AELADGGTLF LDELCEMDLD 240 LQTKLLRFIQ TGTFQKVGSS KMKSVDVRFV CATNRDPWKE VQEGRFREDL YYRLYVIPLH 300 LPPLRERGKD VIEIAYSLLG YMSHEEGKSF VRFAQDVIER FNSYEWPGNV RQLQNVLRNI 360 VVLNNGKEIT LDMLPPPLNQ PVVRQSVAKF IEPDIMTVSD IMPLWMTEKM AIEQAIQACE 420 GNIPRAAGYL DVSPSTIYRK LQAWNSKDEK QNV 453 |
| GO:0005524 F:ATP binding IEA:UniProtKB-KW GO:0017111 F:nucleoside-triphosphatase activity IEA:InterPro GO:0000156 F:phosphorelay response regulator activity IEA:InterPro GO:0043565 F:sequence-specific DNA binding IEA:InterPro GO:0006355 P:regulation of transcription, DNA-templated IEA:UniProtKB-KW GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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