※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Luminescence regulatory protein LuxO
Protein Synonyms/Alias
 
Gene Name
 luxO
Gene Synonyms/Alias
 VIBHAR_02959
Created Date
 3-June-2014
Organism
 Vibrio campbellii (strain ATCC BAA-1116 / BB120)
NCBI Taxa ID
 338187
Phosphorylation
Position
Peptide
Code
Type
References
47 IPDLILLDLRLPDMT D LTP [1]
Reference
 [1]A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi.
 Freeman JA,Bassler BL
 Mol. Microbiol. 1999, Jan;31(2):665-77. [PMID:10027982]
Functional Description From UniProt
 FUNCTION: Acts negatively to control the expression of luminescence. At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon. This repression could be indirect, LuxO could activate a negative regulator of luminescence. At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype
Sequence Annotation From UniProt
 MOD_RES 47 47 4-aspartylphosphate (Probable)
Key Word From UniProt
 ATP-binding; Completeproteome; DNA-binding; Nucleotide-binding; Phosphoprotein; Repressor; Transcription; Transcriptionregulation; Two-componentregulatorysystem
Protein Sequence
 MVEDTASVAA LYRSYLTPLG IDINIVGTGR DAIESLNHRI PDLILLDLRL PDMTGMDVLH 60
 AVKKSHPDVP IIFMTAHGSI DTAVEAMRHG SQDFLIKPCE ADRLRVTVNN AIRKATKLKN 120
 EADNPGNQNY QGFIGSSQTM QQVYRTIDSA ASSKASIFIT GESGTGKEVC AEAIHAASKR 180
 GDKPFIAINC AAIPKDLIES ELFGHVKGAF TGAANDRQGA AELADGGTLF LDELCEMDLD 240
 LQTKLLRFIQ TGTFQKVGSS KMKSVDVRFV CATNRDPWKE VQEGRFREDL YYRLYVIPLH 300
 LPPLRERGKD VIEIAYSLLG YMSHEEGKSF VRFAQDVIER FNSYEWPGNV RQLQNVLRNI 360
 VVLNNGKEIT LDMLPPPLNQ PVVRQSVAKF IEPDIMTVSD IMPLWMTEKM AIEQAIQACE 420
 GNIPRAAGYL DVSPSTIYRK LQAWNSKDEK QNV 453
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0017111   F:nucleoside-triphosphatase activity IEA:InterPro
  GO:0000156   F:phosphorelay response regulator activity IEA:InterPro
  GO:0043565   F:sequence-specific DNA binding IEA:InterPro
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR003593   AAA+_ATPase.
  IPR011006   CheY-like_superfamily.
  IPR009057   Homeodomain-like.
  IPR002197   HTH_Fis.
  IPR027417   P-loop_NTPase.
  IPR001789   Sig_transdc_resp-reg_receiver.
  IPR002078   Sigma_54_int.
  IPR025943   Sigma_54_int_dom_ATP-bd_2.
  IPR025944   Sigma_54_int_dom_CS.
  PF02954   HTH_8.
  PF00072   Response_reg.
  PF00158   Sigma54_activat.
  SM00382   AAA.
  SM00448   REC.
  PS50110   RESPONSE_REGULATORY.
  PS00676   SIGMA54_INTERACT_2.
  PS00688   SIGMA54_INTERACT_3.
  PS50045   SIGMA54_INTERACT_4.